5-Fluorouracil Neurotoxicity in the Absence of Dihydropyrimidine Dehydrogenase Deficiency Case Report

Rebecca Jules, Arushi Thaper, Ryan Foster, Pouya Ameli, Christopher Robinson, Michael Pizzi, Marc Alain Babi, Carolina B. Maciel, Katharina M. Busl, Raju Reddy, William Roth

Research output: Contribution to journalArticlepeer-review

Abstract

5 fluorouracil (5-FU)-related neurotoxicity is a rare and severe complication of 5-FU administration. Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with an increased risk of serious adverse reactions due to its role in 5-FU metabolism. We report a case of acute reversible neurotoxicity with global areas of diffusion restriction in a patient with colorectal adenocarcinoma being treated with leucovorin calcium, 5-fluorouracil, and oxaliplatin (FOLFOX) without DPD deficiency following uridine triacetate administration.

Original languageEnglish (US)
Pages (from-to)366-370
Number of pages5
JournalThe Neurohospitalist
Volume12
Issue number2
DOIs
StatePublished - Apr 2022
Externally publishedYes

Keywords

  • 5 fluorouracil
  • case report
  • dihydropyrimidine dehydrogenase
  • neurotoxicity
  • status epilepticus

ASJC Scopus subject areas

  • Clinical Neurology

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