5-Fluorouracil Neurotoxicity in the Absence of Dihydropyrimidine Dehydrogenase Deficiency Case Report

Rebecca Jules; Arushi Thaper; Ryan Foster; Pouya Ameli; Christopher Robinson; Michael Pizzi; Marc Alain Babi; Carolina B. Maciel; Katharina M. Busl; Raju Reddy; William Roth

doi:10.1177/19418744211068913

5-Fluorouracil Neurotoxicity in the Absence of Dihydropyrimidine Dehydrogenase Deficiency Case Report

Rebecca Jules, Arushi Thaper, Ryan Foster, Pouya Ameli, Christopher Robinson, Michael Pizzi, Marc Alain Babi, Carolina B. Maciel, Katharina M. Busl, Raju Reddy, William Roth

Research output: Contribution to journal › Article › peer-review

Abstract

5 fluorouracil (5-FU)-related neurotoxicity is a rare and severe complication of 5-FU administration. Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with an increased risk of serious adverse reactions due to its role in 5-FU metabolism. We report a case of acute reversible neurotoxicity with global areas of diffusion restriction in a patient with colorectal adenocarcinoma being treated with leucovorin calcium, 5-fluorouracil, and oxaliplatin (FOLFOX) without DPD deficiency following uridine triacetate administration.

Original language	English (US)
Pages (from-to)	366-370
Number of pages	5
Journal	The Neurohospitalist
Volume	12
Issue number	2
DOIs	https://doi.org/10.1177/19418744211068913
State	Published - Apr 2022
Externally published	Yes

Keywords

5 fluorouracil
case report
dihydropyrimidine dehydrogenase
neurotoxicity
status epilepticus

ASJC Scopus subject areas

Clinical Neurology

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10.1177/19418744211068913

Cite this

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title = "5-Fluorouracil Neurotoxicity in the Absence of Dihydropyrimidine Dehydrogenase Deficiency Case Report",

abstract = "5 fluorouracil (5-FU)-related neurotoxicity is a rare and severe complication of 5-FU administration. Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with an increased risk of serious adverse reactions due to its role in 5-FU metabolism. We report a case of acute reversible neurotoxicity with global areas of diffusion restriction in a patient with colorectal adenocarcinoma being treated with leucovorin calcium, 5-fluorouracil, and oxaliplatin (FOLFOX) without DPD deficiency following uridine triacetate administration.",

keywords = "5 fluorouracil, case report, dihydropyrimidine dehydrogenase, neurotoxicity, status epilepticus",

author = "Rebecca Jules and Arushi Thaper and Ryan Foster and Pouya Ameli and Christopher Robinson and Michael Pizzi and Babi, {Marc Alain} and Maciel, {Carolina B.} and Busl, {Katharina M.} and Raju Reddy and William Roth",

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doi = "10.1177/19418744211068913",

language = "English (US)",

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T1 - 5-Fluorouracil Neurotoxicity in the Absence of Dihydropyrimidine Dehydrogenase Deficiency Case Report

AU - Jules, Rebecca

AU - Thaper, Arushi

AU - Foster, Ryan

AU - Ameli, Pouya

AU - Robinson, Christopher

AU - Pizzi, Michael

AU - Babi, Marc Alain

AU - Maciel, Carolina B.

AU - Busl, Katharina M.

AU - Reddy, Raju

AU - Roth, William

N1 - Publisher Copyright: © The Author(s) 2022.

PY - 2022/4

Y1 - 2022/4

N2 - 5 fluorouracil (5-FU)-related neurotoxicity is a rare and severe complication of 5-FU administration. Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with an increased risk of serious adverse reactions due to its role in 5-FU metabolism. We report a case of acute reversible neurotoxicity with global areas of diffusion restriction in a patient with colorectal adenocarcinoma being treated with leucovorin calcium, 5-fluorouracil, and oxaliplatin (FOLFOX) without DPD deficiency following uridine triacetate administration.

AB - 5 fluorouracil (5-FU)-related neurotoxicity is a rare and severe complication of 5-FU administration. Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with an increased risk of serious adverse reactions due to its role in 5-FU metabolism. We report a case of acute reversible neurotoxicity with global areas of diffusion restriction in a patient with colorectal adenocarcinoma being treated with leucovorin calcium, 5-fluorouracil, and oxaliplatin (FOLFOX) without DPD deficiency following uridine triacetate administration.

KW - 5 fluorouracil

KW - case report

KW - dihydropyrimidine dehydrogenase

KW - neurotoxicity

KW - status epilepticus

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JO - The Neurohospitalist

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5-Fluorouracil Neurotoxicity in the Absence of Dihydropyrimidine Dehydrogenase Deficiency Case Report

Abstract

Keywords

ASJC Scopus subject areas

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