5′-Amino-5′-deoxythymidine

Topical Therapeutic Efficacy in Ocular Herpes and Systemic Teratogenic and Toxicity Studies

D. Pavan-Langston, N. H. Park, J. Lass, J. Papale, Daniel Albert, T. Lin, W. H. Prusoff, D. H. Percy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

AdThd (5′-amino-5′-deoxythymidine) is a highly soluble new antiviral drug specifically activated by herpes simplex viral thymidine kinase. Ten and fifteen percent AdThd eye drops were significantly better than placebo in therapy of herpetic keratouveitis in rabbits and the slope of the therapeutic curve of 15% AdThd was similar to that of idoxuridine (IdUrd). Systemic administration of these drugs in the neonatal mouse model revealed no adverse effect in vivo or by histopathologic exam in AdThd or saline-treated animals but that IdUrd was extremely toxic and teratogenic. AdThd is a new, effective and nontoxic specific antiherpes agent.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Volume170
Issue number1
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

Fingerprint

Toxicity
Idoxuridine
Therapeutics
Herpes Simplex
Thymidine Kinase
Ophthalmic Solutions
Poisons
Antiviral Agents
Animals
Placebos
5'-amino-5'-deoxythymidine
Rabbits
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

5′-Amino-5′-deoxythymidine : Topical Therapeutic Efficacy in Ocular Herpes and Systemic Teratogenic and Toxicity Studies. / Pavan-Langston, D.; Park, N. H.; Lass, J.; Papale, J.; Albert, Daniel; Lin, T.; Prusoff, W. H.; Percy, D. H.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 170, No. 1, 01.01.1982, p. 1-7.

Research output: Contribution to journalArticle

Pavan-Langston, D. ; Park, N. H. ; Lass, J. ; Papale, J. ; Albert, Daniel ; Lin, T. ; Prusoff, W. H. ; Percy, D. H. / 5′-Amino-5′-deoxythymidine : Topical Therapeutic Efficacy in Ocular Herpes and Systemic Teratogenic and Toxicity Studies. In: Proceedings of the Society for Experimental Biology and Medicine. 1982 ; Vol. 170, No. 1. pp. 1-7.
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