4D subject-specific inverse modeling of the chick embryonic heart outflow tract hemodynamics

Sevan Goenezen, Venkat Keshav Chivukula, Madeline Midgett, Ly Phan, Sandra Rugonyi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Blood flow plays a critical role in regulating embryonic cardiac growth and development, with altered flow leading to congenital heart disease. Progress in the field, however, is hindered by a lack of quantification of hemodynamic conditions in the developing heart. In this study, we present a methodology to quantify blood flow dynamics in the embryonic heart using subject-specific computational fluid dynamics (CFD) models. While the methodology is general, we focused on a model of the chick embryonic heart outflow tract (OFT), which distally connects the heart to the arterial system, and is the region of origin of many congenital cardiac defects. Using structural and Doppler velocity data collected from optical coherence tomography, we generated 4D ((Formula presented.)) embryo-specific CFD models of the heart OFT. To replicate the blood flow dynamics over time during the cardiac cycle, we developed an iterative inverse-method optimization algorithm, which determines the CFD model boundary conditions such that differences between computed velocities and measured velocities at one point within the OFT lumen are minimized. Results from our developed CFD model agree with previously measured hemodynamics in the OFT. Further, computed velocities and measured velocities differ by (Formula presented.)15 % at locations that were not used in the optimization, validating the model. The presented methodology can be used in quantifications of embryonic cardiac hemodynamics under normal and altered blood flow conditions, enabling an in-depth quantitative study of how blood flow influences cardiac development.

Original languageEnglish (US)
JournalBiomechanics and Modeling in Mechanobiology
DOIs
StateAccepted/In press - Sep 11 2015

Fingerprint

Inverse Modeling
Hemodynamics
Blood Flow
Cardiac
Fluid Model
Hydrodynamics
Computational Fluid Dynamics
Dynamic Model
Blood
Dynamic models
Computational fluid dynamics
Quantification
Methodology
Congenital Heart Disease
Optical Coherence Tomography
Inverse Method
Embryo
Doppler
Growth and Development
Optical tomography

Keywords

  • Cardiac defects
  • cardiac development
  • Chick embryonic heart
  • Congenital heart disease
  • Hemodynamics
  • Inverse methods
  • Outflow tract

ASJC Scopus subject areas

  • Biotechnology
  • Mechanical Engineering
  • Modeling and Simulation

Cite this

4D subject-specific inverse modeling of the chick embryonic heart outflow tract hemodynamics. / Goenezen, Sevan; Chivukula, Venkat Keshav; Midgett, Madeline; Phan, Ly; Rugonyi, Sandra.

In: Biomechanics and Modeling in Mechanobiology, 11.09.2015.

Research output: Contribution to journalArticle

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