4.0 T water proton T1 relaxation times in normal human brain and during acute ethanol intoxication

William Rooney, Jing Huei Lee, Xin Li, Gene Jack Wang, Dinko Franceschi, Charles Jr Springer, Nora D. Volkow

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: It has been reported that acute ethanol intoxication decreases the brain water proton magnetic resonance T1 values, an effect that has been interpreted to indicate brain dehydration during this condition. Because water macromolecular interactions largely determine tissue water T1, another possible explanation for reduced brain water proton T1 values is that the interaction between water and brain macromolecules is altered by ethanol. Methods: A 4.0 T magnetic resonance imaging (MRI) instrument was used to measure brain water proton T1 relaxation times before, during, and after ethanol intoxication (dose, 0.75 mg/kg) in healthy controls. Results: The T1 relaxation times as assessed with MRI were highly reproducible. The mean, paired ethanol-induced differences in T1 were -0.004 ± 0.007 sec (mean ± standard deviation) for white matter and 0.010 ± 0.015 sec for internal gray matter structures, neither of which was significant. Conclusions: This reasonably sensitive measurement does not support the view that tissue water content or water macromolecule interactions are significantly altered in the brain during acute alcohol intoxication in otherwise healthy subjects.

Original languageEnglish (US)
Pages (from-to)830-836
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume24
Issue number6
StatePublished - Jun 2000
Externally publishedYes

Fingerprint

Relaxation time
Protons
Brain
Ethanol
Water
Magnetic resonance
Macromolecules
Tissue
Imaging techniques
Magnetic Resonance Imaging
Alcoholic Intoxication
Dehydration
Water content
Alcohols
Nuclear magnetic resonance
Healthy Volunteers
Magnetic Resonance Spectroscopy

Keywords

  • Acute Alcohol Intoxication
  • Brain Water
  • Magnetic Resonance Imaging
  • T Relaxation Time

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

4.0 T water proton T1 relaxation times in normal human brain and during acute ethanol intoxication. / Rooney, William; Lee, Jing Huei; Li, Xin; Wang, Gene Jack; Franceschi, Dinko; Springer, Charles Jr; Volkow, Nora D.

In: Alcoholism: Clinical and Experimental Research, Vol. 24, No. 6, 06.2000, p. 830-836.

Research output: Contribution to journalArticle

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AU - Lee, Jing Huei

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AU - Wang, Gene Jack

AU - Franceschi, Dinko

AU - Springer, Charles Jr

AU - Volkow, Nora D.

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N2 - Background: It has been reported that acute ethanol intoxication decreases the brain water proton magnetic resonance T1 values, an effect that has been interpreted to indicate brain dehydration during this condition. Because water macromolecular interactions largely determine tissue water T1, another possible explanation for reduced brain water proton T1 values is that the interaction between water and brain macromolecules is altered by ethanol. Methods: A 4.0 T magnetic resonance imaging (MRI) instrument was used to measure brain water proton T1 relaxation times before, during, and after ethanol intoxication (dose, 0.75 mg/kg) in healthy controls. Results: The T1 relaxation times as assessed with MRI were highly reproducible. The mean, paired ethanol-induced differences in T1 were -0.004 ± 0.007 sec (mean ± standard deviation) for white matter and 0.010 ± 0.015 sec for internal gray matter structures, neither of which was significant. Conclusions: This reasonably sensitive measurement does not support the view that tissue water content or water macromolecule interactions are significantly altered in the brain during acute alcohol intoxication in otherwise healthy subjects.

AB - Background: It has been reported that acute ethanol intoxication decreases the brain water proton magnetic resonance T1 values, an effect that has been interpreted to indicate brain dehydration during this condition. Because water macromolecular interactions largely determine tissue water T1, another possible explanation for reduced brain water proton T1 values is that the interaction between water and brain macromolecules is altered by ethanol. Methods: A 4.0 T magnetic resonance imaging (MRI) instrument was used to measure brain water proton T1 relaxation times before, during, and after ethanol intoxication (dose, 0.75 mg/kg) in healthy controls. Results: The T1 relaxation times as assessed with MRI were highly reproducible. The mean, paired ethanol-induced differences in T1 were -0.004 ± 0.007 sec (mean ± standard deviation) for white matter and 0.010 ± 0.015 sec for internal gray matter structures, neither of which was significant. Conclusions: This reasonably sensitive measurement does not support the view that tissue water content or water macromolecule interactions are significantly altered in the brain during acute alcohol intoxication in otherwise healthy subjects.

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