3D model of frequency representation in the cochlear nucleus of the CBA/J mouse

Michael Muniak, Alejandro Rivas, Karen L. Montey, Bradford J. May, Howard W. Francis, David K. Ryugo

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The relationship between structure and function is an invaluable context with which to explore biological mechanisms of normal and dysfunctional hearing. The systematic and topographic representation of frequency originates at the cochlea, and is retained throughout much of the central auditory system. The cochlear nucleus (CN), which initiates all ascending auditory pathways, represents an essential link for understanding frequency organization. A model of the CN that maps frequency representation in 3D would facilitate investigations of possible frequency specializations and pathologic changes that disturb frequency organization. Toward this goal, we reconstructed in 3D the trajectories of labeled auditory nerve (AN) fibers following multiunit recordings and dye injections in the anteroventral CN of the CBA/J mouse. We observed that each injection produced a continuous sheet of labeled AN fibers. Individual cases were normalized to a template using 3D alignment procedures that revealed a systematic and tonotopic arrangement of AN fibers in each subdivision with a clear indication of isofrequency laminae. The combined dataset was used to mathematically derive a 3D quantitative map of frequency organization throughout the entire volume of the CN. This model, available online (http://3D.ryugolab.com/), can serve as a tool for quantitatively testing hypotheses concerning frequency and location in the CN.

Original languageEnglish (US)
Pages (from-to)1510-1532
Number of pages23
JournalJournal of Comparative Neurology
Volume521
Issue number7
DOIs
StatePublished - May 1 2013
Externally publishedYes

Fingerprint

Cochlear Nucleus
Inbred CBA Mouse
Cochlear Nerve
Nerve Fibers
Auditory Pathways
Injections
Cochlea
Hearing
Coloring Agents

Keywords

  • Atlas
  • Auditory nerve
  • Cochleotopy
  • Place-frequency map
  • Tonotopy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

3D model of frequency representation in the cochlear nucleus of the CBA/J mouse. / Muniak, Michael; Rivas, Alejandro; Montey, Karen L.; May, Bradford J.; Francis, Howard W.; Ryugo, David K.

In: Journal of Comparative Neurology, Vol. 521, No. 7, 01.05.2013, p. 1510-1532.

Research output: Contribution to journalArticle

Muniak, Michael ; Rivas, Alejandro ; Montey, Karen L. ; May, Bradford J. ; Francis, Howard W. ; Ryugo, David K. / 3D model of frequency representation in the cochlear nucleus of the CBA/J mouse. In: Journal of Comparative Neurology. 2013 ; Vol. 521, No. 7. pp. 1510-1532.
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