3CLT ABR analyses in a human subject with unilateral extirpation of the inferior colliculus

John D. Durrant, William H. Martin, Barry Hirsch, John Schwegler

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Reported are the results of analyses of three-channel Lissajous trajectories (3CLTs) of the auditory brain stem responses (ABRs) in a human subject in whom a focal lesion of the brain stem was caused by stereotactic radiosurgery, the 'gamma knife'. The surgery caused total destruction of the right inferior colliculus. The results, using multiple measures for defining ABR components, confirm findings from more conventional 2-channel recordings which, in turn, suggested the presence of an intact wave IV but a negligible, if not totally absent, wave V with stimulation of the left (contralateral) ear. The results thus support theories that wave V is generated by crossed pathways and that wave IV is an independent wave generated by the lateral lemniscus. Since magnetic resonance imaging suggested no destruction of tissue below the inferior colliculus, the findings also support theories of wave V generation at or rostral to the inferior colliculus. In practical terms, the results demonstrate the value of multichannel recordings of the ABR in component identification and in interpreting ABR abnormalities.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalHearing Research
Volume72
Issue number1-2
DOIs
StatePublished - Jan 1994
Externally publishedYes

Keywords

  • Auditory brainstem response
  • Auditory pathway
  • Central auditory pathology
  • Inferior colliculus
  • Stereotactic radiosurgery
  • Three-channel Lissajous trajectory

ASJC Scopus subject areas

  • Sensory Systems

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