32P and acute leukemia

Development of leukemia in a patient with hemoglobin Yakima

G. C. Bagby, K. Richert Boe, R. D. Koler

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    In 1954 a then 31-yr-old male was found to have erythrocytosis. Over the ensuing decade he received 72 mCi32P. In 1964 his daughters were found to have erythrocytosis. Further investigation led to the discovery of hemoglobin Yakima, a variant with high oxygen affinity. He received no further therapy and was well until 1975, when he developed the preleukemic syndrome. Within 12 mo he developed acute nonlymphocytic leukemia accompanied by fetal erythropoiesis. Because the initial discovery of this type of hemoglobinopathy came 27 yr after the introduction of 32P for use in the treatment of polycythemia vera, and because there are now known to be more than 39 different high-oxygen-affinity hemoglobins, we anticipate that more patients such as ours have been exposed to 32P. The exposed population should be closely followed, since this will likely permit assessment of the risk of 32P-induced leukemia in a nonneoplastic condition.

    Original languageEnglish (US)
    Pages (from-to)350-354
    Number of pages5
    JournalBlood
    Volume52
    Issue number2
    StatePublished - 1978

    Fingerprint

    Polycythemia
    Leukemia
    Oxygen
    Hemoglobinopathies
    Polycythemia Vera
    Erythropoiesis
    Nuclear Family
    Acute Myeloid Leukemia
    Hemoglobins
    Therapeutics
    Population
    hemoglobin Yakima

    ASJC Scopus subject areas

    • Hematology

    Cite this

    32P and acute leukemia : Development of leukemia in a patient with hemoglobin Yakima. / Bagby, G. C.; Richert Boe, K.; Koler, R. D.

    In: Blood, Vol. 52, No. 2, 1978, p. 350-354.

    Research output: Contribution to journalArticle

    Bagby, GC, Richert Boe, K & Koler, RD 1978, '32P and acute leukemia: Development of leukemia in a patient with hemoglobin Yakima', Blood, vol. 52, no. 2, pp. 350-354.
    Bagby, G. C. ; Richert Boe, K. ; Koler, R. D. / 32P and acute leukemia : Development of leukemia in a patient with hemoglobin Yakima. In: Blood. 1978 ; Vol. 52, No. 2. pp. 350-354.
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