3.0-T whole-heart coronary magnetic resonance angiography: Comparison of gadobenate dimeglumine and gadofosveset trisodium

Fabio S. Raman, Marcelo S. Nacif, George Cater, Neville Gai, Jacquin Jones, Debiao Li, Christopher T. Sibley, Songtao Liu, David A. Bluemke

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Gadolinium enhanced coronary magnetic resonance angiography (MRA) at 3 T appears to be superior to non-contrast methods. Gadofosveset is an intravascular contrast agent that may be well suited to this application. The purpose of this study was to perform an intra-individual comparison of gadofosveset and gadobenate for coronary MRA at 3 T. In this prospective randomized study, 22 study subjects [8 (36 %) male; 27.9 ± 6 years; BMI = 22.8 ± 2 kg/m2] underwent two studies using a contrast-enhanced inversion recovery three-dimensional fast low angle shot MRA at 3 T. The order of contrast agent administration was varied randomly, separated by an average of 30 ± 5 days, using either gadobenate dimeglumine (Gd-BOPTA; Bracco, 0.1 mmol/Kg) or gadofosveset trisodium (MS-325; Lantheus Med, 0.03 mmol/Kg). Acquisition time, signal-to-noise ratio (SNR) of coronary vessels and contrast-to-noise ratio (CNR) were evaluated. Of 308 coronary arteries and veins segment analyzed, overall SNR of coronary arteries and veins segments were not different for the two contrast agents (132 ± 79 for gadofosveset vs. 135 ± 78 for gadobenate, p = 0.69). Coronary artery CNR was greater for gadofosveset in comparison to gadobenate (73.5 ± 46.9 vs. 59.3 ± 75.7 respectively, p = 0.03). Gadofosveset-enhanced MRA images displayed better image quality than gadobenate-enhanced MRA images (2.77 ± 0.61 for gadofosveset vs. 2.11 ± 0.51, p<.001). Inter- and intra-reader variability was excellent (ICC[0.90) for both contrast agents. Gadofosveset trisodium appears to show slightly better performance for coronary MRA at 3 T compared to gadobenate.

Original languageEnglish (US)
Pages (from-to)1085-1094
Number of pages10
JournalInternational Journal of Cardiovascular Imaging
Volume29
Issue number5
DOIs
StatePublished - Jun 2013

Keywords

  • Coronary MRA
  • Gadobenate dimeglumine
  • Gadofosveset trisodium

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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