3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin.

A. C. Ludolph, F. He, Peter Spencer, John Hammerstad, M. Sabri

Research output: Contribution to journalArticle

357 Scopus citations


3-Nitropropionic acid (3-NPA)--a suicide inhibitor of succinate dehydrogenase--is a widely distributed plant and fungal neurotoxin known to induce a damage to basal ganglia, hippocampus, spinal tracts and peripheral nerves in animals. Recent reports from Northern China indicate that 3-NPA is also likely to be responsible for the development of putaminal necrosis with delayed dystonia in children after ingestion of mildewed sugar cane. This article discusses the role of 3-NPA in the causation of the disease in China, its neurotoxic effects in animals and the potential role for this compound as a probe of selective neuronal vulnerability.

Original languageEnglish (US)
Pages (from-to)492-498
Number of pages7
JournalCanadian Journal of Neurological Sciences
Issue number4
Publication statusPublished - Nov 1991


ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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