3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin.

A. C. Ludolph, F. He, Peter Spencer, John Hammerstad, M. Sabri

Research output: Contribution to journalArticle

357 Citations (Scopus)

Abstract

3-Nitropropionic acid (3-NPA)--a suicide inhibitor of succinate dehydrogenase--is a widely distributed plant and fungal neurotoxin known to induce a damage to basal ganglia, hippocampus, spinal tracts and peripheral nerves in animals. Recent reports from Northern China indicate that 3-NPA is also likely to be responsible for the development of putaminal necrosis with delayed dystonia in children after ingestion of mildewed sugar cane. This article discusses the role of 3-NPA in the causation of the disease in China, its neurotoxic effects in animals and the potential role for this compound as a probe of selective neuronal vulnerability.

Original languageEnglish (US)
Pages (from-to)492-498
Number of pages7
JournalCanadian Journal of Neurological Sciences
Volume18
Issue number4
StatePublished - Nov 1991

Fingerprint

Corpus Striatum
Neurotoxins
China
Spinal Nerves
Canes
Succinate Dehydrogenase
Dystonia
Basal Ganglia
Peripheral Nerves
Causality
Suicide
Hippocampus
Necrosis
Eating
3-nitropropionic acid

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin. / Ludolph, A. C.; He, F.; Spencer, Peter; Hammerstad, John; Sabri, M.

In: Canadian Journal of Neurological Sciences, Vol. 18, No. 4, 11.1991, p. 492-498.

Research output: Contribution to journalArticle

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