3-Iodothyronamine (T 1AM): A new chapter of thyroid hormone endocrinology?

Alexandra G. Ianculescu, Thomas S. Scanlan

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


3-Iodothyronamine (T 1AM) is an endogenous thyroid hormone derivative with distinct biological effects that are largely opposite those of thyroid hormone. Administration of T 1AM to rodents results in rapid and profound reduction in body temperature, heart rate, and metabolism. The structural similarities between thyroxine, T 1AM, and monoamine neurotransmitters suggest an intriguing role for T 1AM as both a neuromodulator and a hormone-like molecule that may constitute a part of thyroid hormone action. Several recent studies into its molecular mechanisms of action have shown that T 1AM can target extracellular receptors such as the trace amine-associated receptors and the α 2A adrenergic receptor, modulate the membrane transport of neurotransmitters, and serve as a substrate of specific membrane transport cellular uptake machinery. This review discusses recent T 1AM studies, focusing on both the observed in vivo effects of T 1AM administration and its actions at the molecular level.

Original languageEnglish (US)
Pages (from-to)1338-1344
Number of pages7
JournalMolecular BioSystems
Issue number8
StatePublished - Aug 2010

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology


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