TY - JOUR
T1 - 3-Iodothyronamine (T 1AM)
T2 - A new chapter of thyroid hormone endocrinology?
AU - Ianculescu, Alexandra G.
AU - Scanlan, Thomas S.
PY - 2010/8
Y1 - 2010/8
N2 - 3-Iodothyronamine (T 1AM) is an endogenous thyroid hormone derivative with distinct biological effects that are largely opposite those of thyroid hormone. Administration of T 1AM to rodents results in rapid and profound reduction in body temperature, heart rate, and metabolism. The structural similarities between thyroxine, T 1AM, and monoamine neurotransmitters suggest an intriguing role for T 1AM as both a neuromodulator and a hormone-like molecule that may constitute a part of thyroid hormone action. Several recent studies into its molecular mechanisms of action have shown that T 1AM can target extracellular receptors such as the trace amine-associated receptors and the α 2A adrenergic receptor, modulate the membrane transport of neurotransmitters, and serve as a substrate of specific membrane transport cellular uptake machinery. This review discusses recent T 1AM studies, focusing on both the observed in vivo effects of T 1AM administration and its actions at the molecular level.
AB - 3-Iodothyronamine (T 1AM) is an endogenous thyroid hormone derivative with distinct biological effects that are largely opposite those of thyroid hormone. Administration of T 1AM to rodents results in rapid and profound reduction in body temperature, heart rate, and metabolism. The structural similarities between thyroxine, T 1AM, and monoamine neurotransmitters suggest an intriguing role for T 1AM as both a neuromodulator and a hormone-like molecule that may constitute a part of thyroid hormone action. Several recent studies into its molecular mechanisms of action have shown that T 1AM can target extracellular receptors such as the trace amine-associated receptors and the α 2A adrenergic receptor, modulate the membrane transport of neurotransmitters, and serve as a substrate of specific membrane transport cellular uptake machinery. This review discusses recent T 1AM studies, focusing on both the observed in vivo effects of T 1AM administration and its actions at the molecular level.
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U2 - 10.1039/b926583j
DO - 10.1039/b926583j
M3 - Review article
C2 - 20623079
AN - SCOPUS:77954577284
SN - 1742-206X
VL - 6
SP - 1338
EP - 1344
JO - Molecular BioSystems
JF - Molecular BioSystems
IS - 8
ER -