3-Iodothyronamine: A novel hormone controlling the balance between glucose and lipid utilisation

L. J. Braulke, M. Klingenspor, Andrea De Barber, S. C. Tobias, David Grandy, Thomas (Tom) Scanlan, G. Heldmaier

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

3-Iodothyronamine is considered as a derivate of thyroid hormone as a result of enzymatic deiodination and decarboxylation. The physiological role of thyronamine (T1AM) is not known. The aim of this study was to analyze the metabolic response to T1AM in the Djungarian hamster Phodopus sungorus. We measured the influence of T1AM (50 mg/kg) on metabolic rate (VO2), body temperature (T b) and respiratory quotient (RQ) in this species and in BL/6 mice. T1AM treated hamsters as well as the mice showed a rapid decrease in VO2 and T b, accompanied by a reduction of RQ from normal values of about ∼0.9 to ∼0.70 for several hours. This indicates that carbohydrate utilisation is blocked by the injection of T1AM and that metabolic pathways are rerouted from carbohydrate to lipid utilisation in response to T1AM. This assumption was further supported by the observation that the treatment of T1AM caused ketonuria and a significant loss of body fat. Our results indicate that T1AM has the potential to control the balance between glucose and lipid utilisation in vivo.

Original languageEnglish (US)
Pages (from-to)167-177
Number of pages11
JournalJournal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology
Volume178
Issue number2
DOIs
StatePublished - Feb 2008

Fingerprint

Phodopus
respiratory quotient
hamsters
hormone
carbohydrate
glucose
ketonuria
lipid
Carbohydrates
hormones
Hormones
carbohydrates
Lipids
Glucose
decarboxylation
Ketosis
Decarboxylation
body temperature
mice
thyroid hormones

Keywords

  • Glucose utilisation
  • Hypometabolism
  • Hypothermia
  • Lipid metabolism
  • RQ
  • Thyroid hormone
  • Torpor

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Environmental Science(all)
  • Physiology
  • Physiology (medical)

Cite this

3-Iodothyronamine : A novel hormone controlling the balance between glucose and lipid utilisation. / Braulke, L. J.; Klingenspor, M.; De Barber, Andrea; Tobias, S. C.; Grandy, David; Scanlan, Thomas (Tom); Heldmaier, G.

In: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, Vol. 178, No. 2, 02.2008, p. 167-177.

Research output: Contribution to journalArticle

Braulke, L. J. ; Klingenspor, M. ; De Barber, Andrea ; Tobias, S. C. ; Grandy, David ; Scanlan, Thomas (Tom) ; Heldmaier, G. / 3-Iodothyronamine : A novel hormone controlling the balance between glucose and lipid utilisation. In: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology. 2008 ; Vol. 178, No. 2. pp. 167-177.
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