3-Iodothyronamine: A novel hormone controlling the balance between glucose and lipid utilisation

L. J. Braulke, M. Klingenspor, A. DeBarber, S. C. Tobias, D. K. Grandy, T. S. Scanlan, G. Heldmaier

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

3-Iodothyronamine is considered as a derivate of thyroid hormone as a result of enzymatic deiodination and decarboxylation. The physiological role of thyronamine (T1AM) is not known. The aim of this study was to analyze the metabolic response to T1AM in the Djungarian hamster Phodopus sungorus. We measured the influence of T1AM (50 mg/kg) on metabolic rate (VO2), body temperature (T b) and respiratory quotient (RQ) in this species and in BL/6 mice. T1AM treated hamsters as well as the mice showed a rapid decrease in VO2 and T b, accompanied by a reduction of RQ from normal values of about ∼0.9 to ∼0.70 for several hours. This indicates that carbohydrate utilisation is blocked by the injection of T1AM and that metabolic pathways are rerouted from carbohydrate to lipid utilisation in response to T1AM. This assumption was further supported by the observation that the treatment of T1AM caused ketonuria and a significant loss of body fat. Our results indicate that T1AM has the potential to control the balance between glucose and lipid utilisation in vivo.

Original languageEnglish (US)
Pages (from-to)167-177
Number of pages11
JournalJournal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology
Volume178
Issue number2
DOIs
StatePublished - Feb 1 2008

Keywords

  • Glucose utilisation
  • Hypometabolism
  • Hypothermia
  • Lipid metabolism
  • RQ
  • Thyroid hormone
  • Torpor

ASJC Scopus subject areas

  • Physiology
  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry
  • Animal Science and Zoology
  • Endocrinology

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