24-Hour esophageal pH monitoring before and after medical therapy for reflux esophagitis

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21 Scopus citations


Medical treatment of gastroesophageal reflux disease often results in improvement of symptoms. The purpose of this study was to determine if improvement in symptoms and endoscopic appearance after treatment was associated with a reduction in reflux, as measured with 24-hr pH recordings. Twenty patients with severe chronic reflux esophagitis participated in an eight-week double-blind trial of medical therapy with metoclopramide and cimetidine versus placebo and cimetidine. Significant symptom score improvement was noted in 11 patients. Eleven patients also had improvement in the endoscopic appearance of the esophageal mucosa, and eight of these patients had significant symptom improvement. Initial 24-hr pH recordings were abnormal in all patients, evidenced by an esophageal pH

Original languageEnglish (US)
Pages (from-to)166-171
Number of pages6
JournalDigestive Diseases and Sciences
Issue number2
Publication statusPublished - Feb 1988



  • 24-hr pH monitoring
  • esophageal manometry
  • medical therapy
  • reflux esophagitis

ASJC Scopus subject areas

  • Gastroenterology

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