2 Barrier-1 site pore: An interactive spreadsheet model for two permeating ions

Monique K. Mansoura, David Charles Dawson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An interactive ion channel permeation tutorial was developed using a Microsoft® Excel v5.0 spreadsheet to describe a two barrier, one site channel model by means of Eyring rate theory (ERT). The spreadsheet is inherently interactive so that the user receives immediate feedback about how changes in the energy barrier profile or ion concentrations affect current- voltage relations and single channel conductance. The spreadsheet model is easy to use, allows direct access to intermediate calculated values and all equations, contains graphical displays of parameters and lends itself to customization by a user having only a basic knowledge of spreadsheet operations.

Original languageEnglish (US)
Pages (from-to)255-273
Number of pages19
JournalComputers in Biology and Medicine
Volume28
Issue number3
DOIs
StatePublished - May 1998
Externally publishedYes

Fingerprint

Spreadsheets
Ion Channels
Ions
Energy barriers
Permeation
Display devices
Feedback
Electric potential

Keywords

  • Electrophysiology
  • Energy barrier profile
  • Eyring rate theory
  • Ion channel
  • Pore model
  • Spreadsheet

ASJC Scopus subject areas

  • Computer Science Applications

Cite this

2 Barrier-1 site pore : An interactive spreadsheet model for two permeating ions. / Mansoura, Monique K.; Dawson, David Charles.

In: Computers in Biology and Medicine, Vol. 28, No. 3, 05.1998, p. 255-273.

Research output: Contribution to journalArticle

Mansoura, Monique K. ; Dawson, David Charles. / 2 Barrier-1 site pore : An interactive spreadsheet model for two permeating ions. In: Computers in Biology and Medicine. 1998 ; Vol. 28, No. 3. pp. 255-273.
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