2 Barrier-1 site pore: An interactive spreadsheet model for two permeating ions

Monique K. Mansoura, David Charles Dawson

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

An interactive ion channel permeation tutorial was developed using a Microsoft® Excel v5.0 spreadsheet to describe a two barrier, one site channel model by means of Eyring rate theory (ERT). The spreadsheet is inherently interactive so that the user receives immediate feedback about how changes in the energy barrier profile or ion concentrations affect current- voltage relations and single channel conductance. The spreadsheet model is easy to use, allows direct access to intermediate calculated values and all equations, contains graphical displays of parameters and lends itself to customization by a user having only a basic knowledge of spreadsheet operations.

Original languageEnglish (US)
Pages (from-to)255-273
Number of pages19
JournalComputers in Biology and Medicine
Volume28
Issue number3
DOIs
StatePublished - May 1 1998

Keywords

  • Electrophysiology
  • Energy barrier profile
  • Eyring rate theory
  • Ion channel
  • Pore model
  • Spreadsheet

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics

Fingerprint Dive into the research topics of '2 Barrier-1 site pore: An interactive spreadsheet model for two permeating ions'. Together they form a unique fingerprint.

  • Cite this