2 Barrier-1 site pore: An interactive spreadsheet model for two permeating ions

Monique K. Mansoura; David Charles Dawson

doi:10.1016/S0010-4825(98)00006-7

2 Barrier-1 site pore: An interactive spreadsheet model for two permeating ions

Monique K. Mansoura, David Charles Dawson

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

An interactive ion channel permeation tutorial was developed using a Microsoft® Excel v5.0 spreadsheet to describe a two barrier, one site channel model by means of Eyring rate theory (ERT). The spreadsheet is inherently interactive so that the user receives immediate feedback about how changes in the energy barrier profile or ion concentrations affect current- voltage relations and single channel conductance. The spreadsheet model is easy to use, allows direct access to intermediate calculated values and all equations, contains graphical displays of parameters and lends itself to customization by a user having only a basic knowledge of spreadsheet operations.

Original language	English (US)
Pages (from-to)	255-273
Number of pages	19
Journal	Computers in Biology and Medicine
Volume	28
Issue number	3
DOIs	https://doi.org/10.1016/S0010-4825(98)00006-7
State	Published - May 1998
Externally published	Yes

Keywords

Electrophysiology
Energy barrier profile
Eyring rate theory
Ion channel
Pore model
Spreadsheet

ASJC Scopus subject areas

Health Informatics
Computer Science Applications

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10.1016/S0010-4825(98)00006-7

Cite this

@article{0e0549467f294fcd8b73ef2ce9856379,

title = "2 Barrier-1 site pore: An interactive spreadsheet model for two permeating ions",

abstract = "An interactive ion channel permeation tutorial was developed using a Microsoft{\textregistered} Excel v5.0 spreadsheet to describe a two barrier, one site channel model by means of Eyring rate theory (ERT). The spreadsheet is inherently interactive so that the user receives immediate feedback about how changes in the energy barrier profile or ion concentrations affect current- voltage relations and single channel conductance. The spreadsheet model is easy to use, allows direct access to intermediate calculated values and all equations, contains graphical displays of parameters and lends itself to customization by a user having only a basic knowledge of spreadsheet operations.",

keywords = "Electrophysiology, Energy barrier profile, Eyring rate theory, Ion channel, Pore model, Spreadsheet",

author = "Mansoura, {Monique K.} and Dawson, {David Charles}",

note = "Funding Information: We thank Dr. Richard Hume for suggesting the spreadsheet format for the development of a 2B–1S model and we are grateful to Dr. Robert Macdonald and Dr. Miriam Meisler for comments. This work was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (DK29786, DK45880), the Cystic Fibrosis Foundation, The University of Michigan GI Peptide Center, the National Science Foundation and the Rackham School of Graduate Studies at University of Michigan. ",

year = "1998",

month = may,

doi = "10.1016/S0010-4825(98)00006-7",

language = "English (US)",

volume = "28",

pages = "255--273",

journal = "Computers in Biology and Medicine",

issn = "0010-4825",

publisher = "Elsevier Limited",

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T1 - 2 Barrier-1 site pore

T2 - An interactive spreadsheet model for two permeating ions

AU - Mansoura, Monique K.

AU - Dawson, David Charles

N1 - Funding Information: We thank Dr. Richard Hume for suggesting the spreadsheet format for the development of a 2B–1S model and we are grateful to Dr. Robert Macdonald and Dr. Miriam Meisler for comments. This work was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (DK29786, DK45880), the Cystic Fibrosis Foundation, The University of Michigan GI Peptide Center, the National Science Foundation and the Rackham School of Graduate Studies at University of Michigan.

PY - 1998/5

Y1 - 1998/5

N2 - An interactive ion channel permeation tutorial was developed using a Microsoft® Excel v5.0 spreadsheet to describe a two barrier, one site channel model by means of Eyring rate theory (ERT). The spreadsheet is inherently interactive so that the user receives immediate feedback about how changes in the energy barrier profile or ion concentrations affect current- voltage relations and single channel conductance. The spreadsheet model is easy to use, allows direct access to intermediate calculated values and all equations, contains graphical displays of parameters and lends itself to customization by a user having only a basic knowledge of spreadsheet operations.

AB - An interactive ion channel permeation tutorial was developed using a Microsoft® Excel v5.0 spreadsheet to describe a two barrier, one site channel model by means of Eyring rate theory (ERT). The spreadsheet is inherently interactive so that the user receives immediate feedback about how changes in the energy barrier profile or ion concentrations affect current- voltage relations and single channel conductance. The spreadsheet model is easy to use, allows direct access to intermediate calculated values and all equations, contains graphical displays of parameters and lends itself to customization by a user having only a basic knowledge of spreadsheet operations.

KW - Electrophysiology

KW - Energy barrier profile

KW - Eyring rate theory

KW - Ion channel

KW - Pore model

KW - Spreadsheet

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ER -

2 Barrier-1 site pore: An interactive spreadsheet model for two permeating ions

Abstract

Keywords

ASJC Scopus subject areas

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