[18F] fluoroestradiol radiation dosimetry in human PET studies

D. A. Mankoff, L. M. Peterson, T. J. Tewson, Jeanne Link, J. R. Gralow, M. M. Graham, Kenneth Krohn

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

[18F]16α-fluoroestradiol (FES) is a PET imaging agent useful for the study of estrogen receptors in breast cancer. We estimated the radiation dosimetry for this tracer using data obtained in patient studies. Methods: Time-dependent tissue concentrations of radioactivity were determined from blood samples and PET images in 49 patients (52 studies) after intravenous injection of FES. Radiation absorbed doses were calculated using the procedures of the MIRD committee, taking into account the variation in dose based on the distribution of activities observed in the individual patients. Effective dose equivalent was calculated using International Commission on Radiological Protection Publication 60 weights for the standard woman. Results: The effective dose equivalent was 0.022 mSv/MBq (80 mrem/ mCi). The organ that received the highest dose was the liver (0.13 mGy/MBq [470 mrad/mCi]), followed by the gallbladder (0.10 mGy/MBq [380 mrad/mCi]) and the urinary bladder (0.05 mGy/MBq [190 mrad/mCi]). Conclusion: The organ doses are comparable to those associated with other commonly performed nuclear medicine tests. FES is a useful estrogen receptor-imaging agent, and the potential radiation risks associated with this study are well within accepted limits.

Original languageEnglish (US)
Pages (from-to)679-684
Number of pages6
JournalJournal of Nuclear Medicine
Volume42
Issue number4
StatePublished - 2001
Externally publishedYes

Fingerprint

Radiometry
Estrogen Receptors
Radiation
Nuclear Medicine
Gallbladder
Intravenous Injections
Radioactivity
Publications
Urinary Bladder
Breast Neoplasms
Weights and Measures
Liver

Keywords

  • Dosimetry
  • Estrogen receptor
  • Fluoroestradiol
  • PET

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Mankoff, D. A., Peterson, L. M., Tewson, T. J., Link, J., Gralow, J. R., Graham, M. M., & Krohn, K. (2001). [18F] fluoroestradiol radiation dosimetry in human PET studies. Journal of Nuclear Medicine, 42(4), 679-684.

[18F] fluoroestradiol radiation dosimetry in human PET studies. / Mankoff, D. A.; Peterson, L. M.; Tewson, T. J.; Link, Jeanne; Gralow, J. R.; Graham, M. M.; Krohn, Kenneth.

In: Journal of Nuclear Medicine, Vol. 42, No. 4, 2001, p. 679-684.

Research output: Contribution to journalArticle

Mankoff, DA, Peterson, LM, Tewson, TJ, Link, J, Gralow, JR, Graham, MM & Krohn, K 2001, '[18F] fluoroestradiol radiation dosimetry in human PET studies', Journal of Nuclear Medicine, vol. 42, no. 4, pp. 679-684.
Mankoff DA, Peterson LM, Tewson TJ, Link J, Gralow JR, Graham MM et al. [18F] fluoroestradiol radiation dosimetry in human PET studies. Journal of Nuclear Medicine. 2001;42(4):679-684.
Mankoff, D. A. ; Peterson, L. M. ; Tewson, T. J. ; Link, Jeanne ; Gralow, J. R. ; Graham, M. M. ; Krohn, Kenneth. / [18F] fluoroestradiol radiation dosimetry in human PET studies. In: Journal of Nuclear Medicine. 2001 ; Vol. 42, No. 4. pp. 679-684.
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