[18F]-2-fluoro-2-deoxyglucose transport kinetics as a function of extracellular glucose concentration in malignant glioma, fibroblast and macrophage cells in vitro

Robert C. Burrows, Scott D. Freeman, Aaron W. Charlop, Robert W. Wiseman, Tom C H Adamsen, Kenneth A. Krohn, Alexander M. Spence

Research output: Research - peer-reviewArticle

  • 15 Citations

Abstract

FDG-PET is used to measure the metabolic rate of glucose. Transport and phosphorylation determine the amount of hexose analog that is phosphorylated and trapped. Competition occurs for both events, such that extracellular glucose concentration affects the FDG image. This study investigated the effect of glucose concentration on the rate of FDG accumulation in three cell lines. The results show that extracellular glucose concentration has a greater impact on the rate of FDG accumulation than the relative abundance of GLUT transporter subtypes.

LanguageEnglish (US)
Pages1-9
Number of pages9
JournalNuclear Medicine and Biology
Volume31
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

Fingerprint

Fluorodeoxyglucose F18
Glioma
Fibroblasts
Macrophages
Glucose
In Vitro Techniques
Hexoses
Phosphorylation
Cell Line

Keywords

  • Glioma
  • GLUT isoforms
  • Hexose metabolism
  • Hexose transport
  • Lumped Constant
  • Positron Emission Tomography

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

[18F]-2-fluoro-2-deoxyglucose transport kinetics as a function of extracellular glucose concentration in malignant glioma, fibroblast and macrophage cells in vitro. / Burrows, Robert C.; Freeman, Scott D.; Charlop, Aaron W.; Wiseman, Robert W.; Adamsen, Tom C H; Krohn, Kenneth A.; Spence, Alexander M.

In: Nuclear Medicine and Biology, Vol. 31, No. 1, 01.2004, p. 1-9.

Research output: Research - peer-reviewArticle

Burrows, Robert C. ; Freeman, Scott D. ; Charlop, Aaron W. ; Wiseman, Robert W. ; Adamsen, Tom C H ; Krohn, Kenneth A. ; Spence, Alexander M./ [18F]-2-fluoro-2-deoxyglucose transport kinetics as a function of extracellular glucose concentration in malignant glioma, fibroblast and macrophage cells in vitro. In: Nuclear Medicine and Biology. 2004 ; Vol. 31, No. 1. pp. 1-9
@article{579b8423ccd442149f3505aa4f3b27c1,
title = "[18F]-2-fluoro-2-deoxyglucose transport kinetics as a function of extracellular glucose concentration in malignant glioma, fibroblast and macrophage cells in vitro",
abstract = "FDG-PET is used to measure the metabolic rate of glucose. Transport and phosphorylation determine the amount of hexose analog that is phosphorylated and trapped. Competition occurs for both events, such that extracellular glucose concentration affects the FDG image. This study investigated the effect of glucose concentration on the rate of FDG accumulation in three cell lines. The results show that extracellular glucose concentration has a greater impact on the rate of FDG accumulation than the relative abundance of GLUT transporter subtypes.",
keywords = "Glioma, GLUT isoforms, Hexose metabolism, Hexose transport, Lumped Constant, Positron Emission Tomography",
author = "Burrows, {Robert C.} and Freeman, {Scott D.} and Charlop, {Aaron W.} and Wiseman, {Robert W.} and Adamsen, {Tom C H} and Krohn, {Kenneth A.} and Spence, {Alexander M.}",
year = "2004",
month = "1",
doi = "10.1016/S0969-8051(02)00449-3",
volume = "31",
pages = "1--9",
journal = "International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology",
issn = "0969-8051",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - [18F]-2-fluoro-2-deoxyglucose transport kinetics as a function of extracellular glucose concentration in malignant glioma, fibroblast and macrophage cells in vitro

AU - Burrows,Robert C.

AU - Freeman,Scott D.

AU - Charlop,Aaron W.

AU - Wiseman,Robert W.

AU - Adamsen,Tom C H

AU - Krohn,Kenneth A.

AU - Spence,Alexander M.

PY - 2004/1

Y1 - 2004/1

N2 - FDG-PET is used to measure the metabolic rate of glucose. Transport and phosphorylation determine the amount of hexose analog that is phosphorylated and trapped. Competition occurs for both events, such that extracellular glucose concentration affects the FDG image. This study investigated the effect of glucose concentration on the rate of FDG accumulation in three cell lines. The results show that extracellular glucose concentration has a greater impact on the rate of FDG accumulation than the relative abundance of GLUT transporter subtypes.

AB - FDG-PET is used to measure the metabolic rate of glucose. Transport and phosphorylation determine the amount of hexose analog that is phosphorylated and trapped. Competition occurs for both events, such that extracellular glucose concentration affects the FDG image. This study investigated the effect of glucose concentration on the rate of FDG accumulation in three cell lines. The results show that extracellular glucose concentration has a greater impact on the rate of FDG accumulation than the relative abundance of GLUT transporter subtypes.

KW - Glioma

KW - GLUT isoforms

KW - Hexose metabolism

KW - Hexose transport

KW - Lumped Constant

KW - Positron Emission Tomography

UR - http://www.scopus.com/inward/record.url?scp=1642574313&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642574313&partnerID=8YFLogxK

U2 - 10.1016/S0969-8051(02)00449-3

DO - 10.1016/S0969-8051(02)00449-3

M3 - Article

VL - 31

SP - 1

EP - 9

JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology

T2 - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology

JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology

SN - 0969-8051

IS - 1

ER -