18-Month outcome of clozapine treatment for 100 patients in a state psychiatric hospital

William Wilson, A. M. Claussen

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Objective: The atypical antipsychotic medication clozapine is an effective treatment for refractory psychosis; however, the efficacy of clozapine when used in public mental health programs has yet to he fully characterized. This study assessed the outcome of clozapine treatment in a state hospital. Methods: The medical records of the first 100 patients to receive clozapine in a state hospital, from six months before clozapine treatment through 18 months of treatment, were reviewed. Results: The patients had chronic psychotic disorders that had responded poorly to treatment with conventional antipsychotic meditation. Eighteen months after beginning clozapine, 45 patients were much improved, and 18 were somewhat improved. All except one of the improved patients were continuing clozapine treatment. Forty patients were living in community settings, 59 remained hospitalized, and one had died of an illness unrelated to clozapine. Violent episodes in the hospital decreased during the first six months of clozapine treatment. Thirteen patients had one or two seizures while taking clozapine, 12 of whom successfully continued clozapine treatment. One patient developed agranulocytosis, and one developed leucopenia; each recovered fully after clozapine treatment was discontinued. Conclusions: Clozapine was an effective treatment for refractory psychotic disorders when given as a part of routine state hospital treatment.

Original languageEnglish (US)
Pages (from-to)386-389
Number of pages4
JournalPsychiatric Services
Volume46
Issue number4
StatePublished - 1995

Fingerprint

State Hospitals
psychiatric hospital
Clozapine
Psychiatric Hospitals
psychosis
seizure
meditation
Psychotic Disorders
Therapeutics
medication
illness
mental health
Antipsychotic Agents
community
Meditation
Agranulocytosis
Leukopenia
Medical Records
Mental Health
Seizures

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Public Health, Environmental and Occupational Health
  • Health(social science)
  • Health Professions(all)

Cite this

18-Month outcome of clozapine treatment for 100 patients in a state psychiatric hospital. / Wilson, William; Claussen, A. M.

In: Psychiatric Services, Vol. 46, No. 4, 1995, p. 386-389.

Research output: Contribution to journalArticle

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