β2-Microglobulin from serum associates with several class I antigens expressed on the surface of mouse L-cells

Carmelo Bernabeu, Richard Maziarz, Cornelis Murre, Cox Terhorst

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Bovine β2-microglobulin (β2-m) present in fetal calf serum (FCS) is able to replace endogenous β2-m associated with several class I antigens from human and mouse cells maintained in culture [Bernabeu et al. (1984) Nature, Lond. 308, 642-645]. Here we show that human HLA-A2 and HLA-B7, as well as mouse H-2Ld and H-2Dd heavy chains expressed after gene transfer in mouse L-cells, associate to a large extent with bovine β2-m. We also demonstrate that bovine β2-m associated with the endogenous H-2Kk/Dk heavy chains generates an antibody response when L-cells are injected into syngeneic C3H mice.

Original languageEnglish (US)
Pages (from-to)955-960
Number of pages6
JournalMolecular Immunology
Volume22
Issue number8
DOIs
StatePublished - Aug 1985

    Fingerprint

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

Cite this