β2 microglobulin as a surrogate marker for HIV infection: Good correlation with CD4 counts

A. Wanchu, S. Arora, A. Bhatnagar, A. Sud, P. Bambery, S. Singh

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

To determine if beta-2 microglobulin (β2M) levels were elevated in our HIV infected patient population and if it could be used as a surrogate marker for disease progression. Thirty-eight HIV infected individuals and 26 age and sex-matched controls were studied. Measurement of CD4 cell count was carried out on a flow cytometer using anti-human CD4 monoclonal antibody and β2M was measured by an enzyme immunoassay. Mean levels of HIV infected individuals were 1.29±0.52 mg/L and were significantly higher than 0.74±0.07 mg/L, the value of controls (p value <0.01). There was a negative correlation between CD4 counts and β2M levels (r-value -0.79, p value <0.001). β2M levels in HIV infected individuals who have no opportunistic infection are elevated and these levels correlate with the CD4 counts. β2M can be used for the clinical follow-up of patients with HIV infection.

Original languageEnglish (US)
Pages (from-to)298-301
Number of pages4
JournalIndian Journal of Pathology and Microbiology
Volume47
Issue number2
StatePublished - Apr 1 2004

Keywords

  • CD4 counts
  • Disease progression
  • HIV infection
  • β microglobulin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Microbiology (medical)

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    Wanchu, A., Arora, S., Bhatnagar, A., Sud, A., Bambery, P., & Singh, S. (2004). β2 microglobulin as a surrogate marker for HIV infection: Good correlation with CD4 counts. Indian Journal of Pathology and Microbiology, 47(2), 298-301.