Abstract
To determine if beta-2 microglobulin (β2M) levels were elevated in our HIV infected patient population and if it could be used as a surrogate marker for disease progression. Thirty-eight HIV infected individuals and 26 age and sex-matched controls were studied. Measurement of CD4 cell count was carried out on a flow cytometer using anti-human CD4 monoclonal antibody and β2M was measured by an enzyme immunoassay. Mean levels of HIV infected individuals were 1.29±0.52 mg/L and were significantly higher than 0.74±0.07 mg/L, the value of controls (p value <0.01). There was a negative correlation between CD4 counts and β2M levels (r-value -0.79, p value <0.001). β2M levels in HIV infected individuals who have no opportunistic infection are elevated and these levels correlate with the CD4 counts. β2M can be used for the clinical follow-up of patients with HIV infection.
Original language | English (US) |
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Pages (from-to) | 298-301 |
Number of pages | 4 |
Journal | Indian Journal of Pathology and Microbiology |
Volume | 47 |
Issue number | 2 |
State | Published - Apr 2004 |
Keywords
- CD4 counts
- Disease progression
- HIV infection
- β microglobulin
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Microbiology (medical)