β1 integrins control the formation of cell chains in the adult rostral migratory stream

Richard Belvindrah, Sabine Hankel, John Walker, Bruce Patton, Ulrich Müller

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

The subventricular zone (SVZ) of the lateral ventricle is the major site of neurogenesis in the adult brain. Neuroblasts that are born in the SVZ migrate as chains along the rostral migratory stream (RMS) to the olfactory bulb. Little is known about the mechanisms that control interactions between neuroblasts during their migration. Here we show that migrating neuroblasts express β1integrins and that the integrin ligand laminin is localized to cell chains. Using genetically modified mice and time-lapse video recordings of SVZ explants, we demonstrate that β1 integrins and laminin promote the formation of cell chains. Laminin also induces the aggregation of purified neuroblasts. We conclude that the formation of cell chains in the RMS is controlled in part by β1 integrins via binding to laminin. In addition, we provide evidence that β1 class integrins are required for the maintenance of the glial tubes and that defects in the glial tubes lead to the ectopic migration of neuroblasts into the surrounding tissue.

Original languageEnglish (US)
Pages (from-to)2704-2717
Number of pages14
JournalJournal of Neuroscience
Volume27
Issue number10
DOIs
StatePublished - Mar 7 2007

Fingerprint

Lateral Ventricles
Integrins
Laminin
Neuroglia
Video Recording
Olfactory Bulb
Neurogenesis
Maintenance
Ligands
Brain

Keywords

  • β1 integrins
  • CNS
  • Laminin
  • Migration
  • RMS
  • SVZ

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

β1 integrins control the formation of cell chains in the adult rostral migratory stream. / Belvindrah, Richard; Hankel, Sabine; Walker, John; Patton, Bruce; Müller, Ulrich.

In: Journal of Neuroscience, Vol. 27, No. 10, 07.03.2007, p. 2704-2717.

Research output: Contribution to journalArticle

Belvindrah, Richard ; Hankel, Sabine ; Walker, John ; Patton, Bruce ; Müller, Ulrich. / β1 integrins control the formation of cell chains in the adult rostral migratory stream. In: Journal of Neuroscience. 2007 ; Vol. 27, No. 10. pp. 2704-2717.
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