β-carotene in HIV infection: An extended evaluation

Gregg O. Coodley, Marcia K. Coodley, Robert Lusk, Terrence R. Green, Anthony C. Bakke, David Wilson, Danny Wachenheim, Gary Sexton, Catherine Salveson

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Objective: Several small short-term intervention studies have suggested that β-carotene supplementation in HIV-infected patients can increase the number of various immune cells including CD4 cells. This prospective double-blinded study was designed to investigate whether β-carotene supplementation would result in this immune-enhancement in a larger number of patients over a longer time period. Methods: HIV-positive patients were randomly assigned to receive either 60 mg β-carotene orally three times daily or a matched placebo. In addition, all patients received a multivitamin supplement. Patients were evaluated at baseline, 1 month, and 3 months for T-cell quantitative subsets, natural killer cells, HIV p24 antigen, β-carotene levels, complete blood counts and chemistry batteries. Body weights and Karnofsky scores were evaluated at each visit. Results: Seventy-two patients signed informed consent forms and entered the study. Except for serum β-carotene concentration, there were no statistically significant differences (P < 0.05) between the treatment (60 mg β-carotene three limes daily and multivitamins) and placebo (placebo and multivitamins) groups at baseline or after either 1 or 3 months of treatment. Discussion: Earlier studies suggesting that β-carotene supplementation increased levels of immune cells in HIV-infected patients were not replicated in this study. The addition of a multivitamin supplement to both arms of this study may have masked any difference between the two groups. However, on the basis of the results of this study, we would not recommend supplementation with high doses of β-carotene for HIV-infected patients.

Original languageEnglish (US)
Pages (from-to)967-973
Number of pages7
JournalAIDS
Volume10
Issue number9
DOIs
StatePublished - Jan 1 1996

Keywords

  • HIV infection
  • Immune function
  • Retinol
  • Vitamins
  • β-carotene

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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  • Cite this

    Coodley, G. O., Coodley, M. K., Lusk, R., Green, T. R., Bakke, A. C., Wilson, D., Wachenheim, D., Sexton, G., & Salveson, C. (1996). β-carotene in HIV infection: An extended evaluation. AIDS, 10(9), 967-973. https://doi.org/10.1097/00002030-199610090-00006