Adrenergic control of atrial natriuretic factor (ANF) secretion was studied using perifused, dispersed atrial myocytes. ANF secretion was stimulated by as little as 1 nM epinephrine (EPI) or the β-adrenergic agonist isoproterenol (ISO). The response to EPI was completely blocked by equimolar propranolol but not by phenoxybenzamine suggesting that, at least in this system, the adrenergic control of ANF secretion is mediated by β-adrenergic receptors.
- Adrenergic receptor
- Atrial natriuretic factor
ASJC Scopus subject areas
- Clinical Biochemistry
- Cellular and Molecular Neuroscience