α-Tocopherol (vitamin E) stimulates cyclic AMP production in human peripheral mononuclear cells and alters immune function

Sonemany Salinthone, Amelia R. Kerns, Vivian Tsang, Daniel W. Carr

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

α-Tocopherol, the most biologically active member of the vitamin E family of fat soluble compounds, exhibits both antioxidant and anti-inflammatory properties. However, its mechanisms of action are not fully understood. Here, we show that, unlike other antioxidants, α-tocopherol stimulates the production of cyclic adenosine monophosphate (cAMP). Inhibitor studies demonstrate that the prostaglandin EP2 and EP4 receptors and adenylyl cyclases mediate the effects of α-tocopherol on cAMP production. Additionally, we show that α-tocopherol attenuates pro-inflammatory cytokine and chemokine production. This study provides novel evidence that α-tocopherol stimulates cAMP signaling, suggesting a mechanism of action for the immunomodulatory effects of vitamin E.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalMolecular Immunology
Volume53
Issue number3
DOIs
StatePublished - Mar 1 2013

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Keywords

  • CAMP
  • Chemokine
  • Cytokine
  • Cα-Tocopherol
  • Inflammation
  • Signal transduction

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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