α-Melanocyte-Stimulating Hormonelike Immunoreactivity Is Increased in Cerebrospinal Fluid of Patients With Parkinson's Disease

Innocenzo Rainero, Jeffrey Kaye, Conrad May, Raymon Durso, Douglas I. Katz, Martin L. Albert, Nicola Wolfe, L. Pinessi, R. P. Friedland, Stanley I. Rapoport

Research output: Contribution to journalArticle

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Abstract

We measured α-melanocyte—stimulating hormonelike immunoreactivity in cerebrospinal fluid of 12 healthy control subjects and nine patients with Parkinson's disease, four of whom had never been treated. Mean cerebrospinal fluid α-melanocyte—stimulating hormonelike immunoreactivity concentration was twofold greater in parkinsonian patients (44.1 ± 9.3 [SD] pg/mL) as compared with control subjects (21.8 ± 10.0 pg/ mL). No significant correlation was found between cerebrospinal fluid α-melanocyte—stimulating hormonelike imminoreactivity concentrations and patient age, disease severity, or duration of disease. These results suggest a functional relation between dopaminergic and melanotropinergic systems in the human brain.

Original languageEnglish (US)
Pages (from-to)1224-1227
Number of pages4
JournalArchives of Neurology
Volume45
Issue number11
DOIs
StatePublished - 1988
Externally publishedYes

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Melanocytes
Parkinson Disease
Cerebrospinal Fluid
Healthy Volunteers
Brain
Parkinson's Disease

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

α-Melanocyte-Stimulating Hormonelike Immunoreactivity Is Increased in Cerebrospinal Fluid of Patients With Parkinson's Disease. / Rainero, Innocenzo; Kaye, Jeffrey; May, Conrad; Durso, Raymon; Katz, Douglas I.; Albert, Martin L.; Wolfe, Nicola; Pinessi, L.; Friedland, R. P.; Rapoport, Stanley I.

In: Archives of Neurology, Vol. 45, No. 11, 1988, p. 1224-1227.

Research output: Contribution to journalArticle

Rainero, I, Kaye, J, May, C, Durso, R, Katz, DI, Albert, ML, Wolfe, N, Pinessi, L, Friedland, RP & Rapoport, SI 1988, 'α-Melanocyte-Stimulating Hormonelike Immunoreactivity Is Increased in Cerebrospinal Fluid of Patients With Parkinson's Disease', Archives of Neurology, vol. 45, no. 11, pp. 1224-1227. https://doi.org/10.1001/archneur.1988.00520350062017
Rainero, Innocenzo ; Kaye, Jeffrey ; May, Conrad ; Durso, Raymon ; Katz, Douglas I. ; Albert, Martin L. ; Wolfe, Nicola ; Pinessi, L. ; Friedland, R. P. ; Rapoport, Stanley I. / α-Melanocyte-Stimulating Hormonelike Immunoreactivity Is Increased in Cerebrospinal Fluid of Patients With Parkinson's Disease. In: Archives of Neurology. 1988 ; Vol. 45, No. 11. pp. 1224-1227.
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AU - Durso, Raymon

AU - Katz, Douglas I.

AU - Albert, Martin L.

AU - Wolfe, Nicola

AU - Pinessi, L.

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