We measured α-melanocyte—stimulating hormonelike immunoreactivity in cerebrospinal fluid of 12 healthy control subjects and nine patients with Parkinson's disease, four of whom had never been treated. Mean cerebrospinal fluid α-melanocyte—stimulating hormonelike immunoreactivity concentration was twofold greater in parkinsonian patients (44.1 ± 9.3 [SD] pg/mL) as compared with control subjects (21.8 ± 10.0 pg/ mL). No significant correlation was found between cerebrospinal fluid α-melanocyte—stimulating hormonelike imminoreactivity concentrations and patient age, disease severity, or duration of disease. These results suggest a functional relation between dopaminergic and melanotropinergic systems in the human brain.
|Original language||English (US)|
|Number of pages||4|
|Journal||Archives of Neurology|
|State||Published - Nov 1988|
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology