α-Melanocyte-Stimulating Hormonelike Immunoreactivity Is Increased in Cerebrospinal Fluid of Patients With Parkinson's Disease

Innocenzo Rainero, Jeffrey A. Kaye, Conrad May, Raymon Durso, Douglas I. Katz, Martin L. Albert, Nicola Wolfe, L. Pinessi, R. P. Friedland, Stanley I. Rapoport

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

We measured α-melanocyte—stimulating hormonelike immunoreactivity in cerebrospinal fluid of 12 healthy control subjects and nine patients with Parkinson's disease, four of whom had never been treated. Mean cerebrospinal fluid α-melanocyte—stimulating hormonelike immunoreactivity concentration was twofold greater in parkinsonian patients (44.1 ± 9.3 [SD] pg/mL) as compared with control subjects (21.8 ± 10.0 pg/ mL). No significant correlation was found between cerebrospinal fluid α-melanocyte—stimulating hormonelike imminoreactivity concentrations and patient age, disease severity, or duration of disease. These results suggest a functional relation between dopaminergic and melanotropinergic systems in the human brain.

Original languageEnglish (US)
Pages (from-to)1224-1227
Number of pages4
JournalArchives of Neurology
Volume45
Issue number11
DOIs
StatePublished - Nov 1988

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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    Rainero, I., Kaye, J. A., May, C., Durso, R., Katz, D. I., Albert, M. L., Wolfe, N., Pinessi, L., Friedland, R. P., & Rapoport, S. I. (1988). α-Melanocyte-Stimulating Hormonelike Immunoreactivity Is Increased in Cerebrospinal Fluid of Patients With Parkinson's Disease. Archives of Neurology, 45(11), 1224-1227. https://doi.org/10.1001/archneur.1988.00520350062017