TY - JOUR
T1 - β2-Microglobulin from serum associates with several class I antigens expressed on the surface of mouse L-cells
AU - Bernabeu, Carmelo
AU - Maziarz, Richard
AU - Murre, Cornelis
AU - Terhorst, Cox
PY - 1985/8
Y1 - 1985/8
N2 - Bovine β2-microglobulin (β2-m) present in fetal calf serum (FCS) is able to replace endogenous β2-m associated with several class I antigens from human and mouse cells maintained in culture [Bernabeu et al. (1984) Nature, Lond. 308, 642-645]. Here we show that human HLA-A2 and HLA-B7, as well as mouse H-2Ld and H-2Dd heavy chains expressed after gene transfer in mouse L-cells, associate to a large extent with bovine β2-m. We also demonstrate that bovine β2-m associated with the endogenous H-2Kk/Dk heavy chains generates an antibody response when L-cells are injected into syngeneic C3H mice.
AB - Bovine β2-microglobulin (β2-m) present in fetal calf serum (FCS) is able to replace endogenous β2-m associated with several class I antigens from human and mouse cells maintained in culture [Bernabeu et al. (1984) Nature, Lond. 308, 642-645]. Here we show that human HLA-A2 and HLA-B7, as well as mouse H-2Ld and H-2Dd heavy chains expressed after gene transfer in mouse L-cells, associate to a large extent with bovine β2-m. We also demonstrate that bovine β2-m associated with the endogenous H-2Kk/Dk heavy chains generates an antibody response when L-cells are injected into syngeneic C3H mice.
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U2 - 10.1016/0161-5890(85)90082-3
DO - 10.1016/0161-5890(85)90082-3
M3 - Article
C2 - 3900696
AN - SCOPUS:0022003131
SN - 0161-5890
VL - 22
SP - 955
EP - 960
JO - Molecular Immunology
JF - Molecular Immunology
IS - 8
ER -