Abstract
α-Tocopherol, the most biologically active member of the vitamin E family of fat soluble compounds, exhibits both antioxidant and anti-inflammatory properties. However, its mechanisms of action are not fully understood. Here, we show that, unlike other antioxidants, α-tocopherol stimulates the production of cyclic adenosine monophosphate (cAMP). Inhibitor studies demonstrate that the prostaglandin EP2 and EP4 receptors and adenylyl cyclases mediate the effects of α-tocopherol on cAMP production. Additionally, we show that α-tocopherol attenuates pro-inflammatory cytokine and chemokine production. This study provides novel evidence that α-tocopherol stimulates cAMP signaling, suggesting a mechanism of action for the immunomodulatory effects of vitamin E.
Original language | English (US) |
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Pages (from-to) | 173-178 |
Number of pages | 6 |
Journal | Molecular Immunology |
Volume | 53 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2013 |
Keywords
- CAMP
- Chemokine
- Cytokine
- Cα-Tocopherol
- Inflammation
- Signal transduction
ASJC Scopus subject areas
- Immunology
- Molecular Biology