• Belknap, John (PI)

Project: Research project

Project Details


The first objective of the proposed work is to continue bidirectional
selective breeding to produce three lines of mice which differ maximally
from one another in their genetically-based sensitivity to analgesic
(antinociceptive) effects of opiate drugs (narcotic analgesics). To this
end, three lines will be maintained: one will be selectively bred in the
direction of a high antinociceptive response, another in the direction of a
low antinociceptive response, and the third will be a (nonselected) control
line. Selection will be based on latencies on the hot plate assay in
response to levorphanol, morphine-like opioid agonist. The second
objective is to conduct studies to determine the mechanisms which account
for the selection line differences, and a search made for other effects of
opioids which may share common mechanisms with the antinociceptive
response. The third objective is to screen a considerable number of novel
analgesics using these selection lines to determine the extent to which
their mechanisms of action overlap with levorphanol or morphine. These animals should be a valuable resource for research concerning the
actions of analgesic drugs and mechanisms of pain in general. Every
reasonable effort will be made to make these selection lines available to
other investigators who might wish to use them.
Effective start/end date2/1/8411/30/87


  • National Institutes of Health


  • Medicine(all)


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