• Barr-Gillespie, Peter (PI)
  • Brownell, William (PI)
  • Freeman, Elaine (PI)
  • Mattox, Douglas (PI)
  • Herdman, Susan (PI)
  • Sachs, Murray (PI)
  • Niparko, John K. (PI)
  • Niparko, John (PI)
  • Welby, John (PI)
  • Minor, Lloyd Brooks (PI)
  • Manis, Paul (PI)
  • Young, Eric Daniel (PI)
  • Shelhamer, Mark (PI)
  • Zee, David (PI)
  • Ryugo, David (PI)
  • May, Bradford (PI)

Project: Research project

Project Details


The focus of this Research and Training Center in Hearing and Balance is
the study of labyrinthine from the biophysics of hair cell mechanisms to
the rehabilitation of patients with unilateral hearing loss. The research
we propose is focused on three closely related areas: mechanisms of hair
cell damage; testing and rehabilitation of patients with unilateral
vestibular lesions; and signal processing in the brainstem auditory
system. One group of three projects focuses on in vitro and in vivo
studies of these mechanisms of action of pharmacological and environmental
ototoxins and on ways to mitigate these effects. A group of four projects
attempts to devise better ways to evaluate otolith function, to learn more
about vestibula-ocular adaptation with implications for the design of
physical therapies, to examine effects of anti-motion sickness
medications, and to test the efficacy of physical therapy on improvement
of vestibular function in patients with unilateral lesions. A final group
of four projects focuses on the role of on and of other sensory inputs on
signal processing in the cochlear nucleus. Our proposed training program
will integrate training in hearing and balance and will provide for strong
interactions between basic science and clinical trainees and faculty.
This program takes advantage of the Hopkins strength in basic and clinical
science. Among a number of novel features that build on an already
established training program are the development of a clinical rotation
for basic science trainees, an integrated research and clinical residency
for selected clinician scientists, a neuro-otology postdoctoral program
for otolaryngologists, neurologists, audiologists and physical therapists,
and a sabbatical plan to bring scientists and clinicians to our Center
from institutions with inadequate research environments. We propose a
series of continuing education symposia in hearing and balance for health
professionals that will address important clinical issues with a firm
grounding in basic research. We will offer a continuing studies course
that will make current information on hearing and balance function and
disorders accessible to the local professional and lay communities.
Finally, we propose to develop a broad information dissemination program
to reach health professionals, the lay public, opinion leaders and
patients. This program will take advantage of the extensive Hopkins
Public Affairs machinery.
Effective start/end date9/30/908/31/01


  • National Institutes of Health


  • Medicine(all)
  • Neuroscience(all)


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