REPRODUCTION IN MUTANT SHEEP USED FOR THE STUDY OF HYPERBILIRUBINEMIA

  • Samuels, Mary (PI)
  • Norris, David (PI)
  • Alfrey, Allen (PI)
  • Kaehny, William D. (PI)
  • Woodward, John (PI)
  • Holmes, Joseph (PI)
  • Robbins, Richard (PI)
  • Emlen, J. Woodruff (PI)
  • Betz, George (PI)
  • Linas, Stuart (PI)
  • Kohler, Peter (PI)
  • Kelleher, Stephen (PI)
  • Stemmer, Salomon (PI)
  • Stumpf, David (PI)
  • vandepol, Christine (PI)
  • Laudenslager, Mark (PI)
  • Emlen, Woodruff (PI)
  • Teitelbaum, Issac (PI)
  • Kern, Fred (PI)
  • Reite, Martin (PI)
  • Hasiba, U.T.E. (PI)
  • Schholey, Robert (PI)
  • Goff, John Sawyer (PI)
  • Shrier, Robert (PI)
  • Robertson, R. Paul (PI)
  • Boyson, Sally (PI)
  • Neldner, Kenneth (PI)
  • Schooley, Robert (PI)
  • Crapo, Phyllis (PI)
  • Gordon, Stuart (PI)
  • Horsburgh, Charles (PI)
  • Hoffer, Barry (PI)
  • Hammermeister, Karl (PI)
  • Runn, Paul (PI)
  • Reiter, Michael (PI)
  • Baum, Kenneth (PI)
  • Gill, Kathyrn (PI)
  • Thompson, David (PI)
  • Hofeldt, Fred (PI)
  • Bloedow, Duane (PI)
  • Fuenzalida, Charles (PI)
  • Echel, Robert (PI)
  • Distiller, Lawrence (PI)
  • Hollister, Alan (PI)
  • Byyny, Richard L. (PI)
  • Hamilos, Daniel (PI)
  • Collier, David Harris (PI)
  • Nies, Alan (PI)
  • Kolterman, Orville (PI)
  • Phillip, Michael (PI)
  • Stegall, Mark (PI)
  • Levin, Myron (PI)
  • Franks, John (PI)
  • Hamridge, Michael (PI)
  • Huff, J.C. (PI)
  • Goodwin, Diane (PI)
  • Olefsky, Jerrold (PI)
  • Burks, Jack (PI)
  • Gartner, Stephanie (PI)
  • Kumpe, David (PI)
  • Metz, Stewart (PI)
  • Bernanu, Paulos (PI)
  • Braun, Thomas (PI)
  • Gross, Cordell (PI)
  • Claman, Henry (PI)
  • Reveille, Matthew (PI)
  • Block, Matthew (PI)
  • Savage, Susan (PI)
  • Huff, J. Clark (PI)
  • Franklin, Gary M. (PI)
  • Tan, Eng (PI)
  • Bichet, Daniel (PI)
  • Groves, Bertron (PI)
  • Tangel, Douglas (PI)
  • Anderson, Robert (PI)
  • [No Value], Bo Y. (PI)
  • Wettlaufer, John (PI)
  • Wambolt, Marianne (PI)
  • Irons, Richard (PI)
  • Kruse, Carol (PI)
  • Bynny, Richard (PI)
  • Steigerwald, James (PI)
  • Schwartz, M. (PI)
  • Franks, Ronald (PI)
  • Reeve, E. Basil (PI)
  • Singh, Shailini (PI)
  • Berhanu, Paulos (PI)
  • Gines, Pere (PI)
  • Albrecht, Bruce (PI)
  • Schriber, Robert (PI)
  • Canaris, G.A.Y. (PI)
  • Dubofsky, Steven (PI)
  • Hwang, Paul (PI)
  • Kindt, Glenn (PI)
  • Cohn, David (PI)
  • Drabkin, H. (PI)
  • Glode, L. Micheal (PI)
  • Dubovsky, Steven (PI)
  • Golitz, Loren (PI)
  • Schlaff, William (PI)
  • Rosenberg, Neil L. (PI)
  • Glode, Michael (PI)
  • Hay, William (PI)
  • Reveille, R. Matthew (PI)
  • Ridgeway, Eli Chester (PI)
  • Kern, Fred (PI)
  • Stuart, L. (PI)
  • Krueger, Michael (PI)
  • Frontiera, Michael (PI)
  • Manco-Johnson, Michael (PI)
  • Franklion, Gary (PI)
  • Horwitz, Lawrence (PI)
  • Markley, Herbert (PI)
  • Marr, J. Joseph (PI)
  • Freed, Curt (PI)
  • Boyko, Edward (PI)
  • Petty, Thomas (PI)
  • Brand, Elliot (PI)
  • Robbins, Laurence (PI)
  • Teitelbaum, Isaac (PI)
  • Daneshgari, Firouz (PI)
  • Cosby, Robert L. (PI)
  • Rector, William G. (PI)
  • Ahnen, Dennis (PI)
  • St. Geme, Joseph W. (PI)
  • Halgrimson, Charles (PI)
  • Jacobson, Eugene (PI)
  • King, Talmadge (PI)
  • Moore, Lorna (PI)
  • Badesch, David B. (PI)
  • Groah, Suzanne (PI)
  • Champman, Arlene (PI)
  • Yucha, Carolyn (PI)
  • Shapiro, Leland (PI)
  • Harris, R. (PI)
  • Morelli, Joseph (PI)
  • Schrier, Robert W. (PI)
  • Garg, Satish (PI)
  • Zisman, Lawrence S. (PI)
  • Ksiazek, Karen (PI)
  • Davy, Kevin (PI)
  • Brandenburg, Suzanne (PI)
  • Spahn, Joseph (PI)
  • Weintraub, Phillip (PI)
  • Fennelly, Kevin (PI)
  • Crawford, Fred (PI)
  • Walsh, Patrick (PI)
  • Francis, Coni (PI)
  • Kraft, Andrew (PI)
  • Wolfel, Eugene (PI)
  • Carroll, John (PI)
  • Burchenal, J. (PI)
  • Hamman, Richard (PI)
  • Oman, Kathleen (PI)
  • Melanson, Edward (PI)
  • Kotzin, Brian (PI)
  • Wamboldt, Marianne (PI)
  • Bilir, Bahri (PI)
  • Lowes, Brian (PI)
  • Bessesen, Daniel Holland (PI)
  • Benson, Constance (PI)
  • Routes, Jack (PI)
  • Rowley, Jo Anne (PI)
  • Zamora, Martin (PI)
  • Freedman, Robert (PI)
  • Deitrich, Richard (PI)
  • Stolleer, Norman (PI)
  • Liliehei, Kevin (PI)
  • Tornblom, Kjell (PI)
  • Colton, Josh (PI)
  • Cook, James (PI)
  • Bessessen, Daniel (PI)
  • Martin, Richard (PI)
  • Kraft, Monica (PI)
  • Bender, Bruce (PI)
  • Peloquin, Charles Arthur (PI)
  • Horton, Tracy (PI)
  • Thompson, Holly (PI)
  • Wenzel, Sally (PI)
  • Cagnoni, Pablo (PI)
  • Langmack, Esther (PI)
  • Kosmiski, Lisa (PI)
  • Buchanan, Thomas (PI)
  • Eisenbarth, George (PI)
  • Trouillot, Thomas (PI)
  • Moore, Lorna G. (PI)
  • Desouza, Christopher (PI)
  • Hardin, Dana (PI)
  • Jones, Pamela (PI)
  • Rose, Cecile (PI)
  • Liu, Andy (PI)
  • Guzelian, Philip (PI)
  • Jones, J.I.M. (PI)
  • Gozansky, Wendolyn (PI)
  • Donahoo, W. Troy (PI)
  • Sonko, Bakary (PI)
  • Gottschall, Eva (PI)
  • Hedlund, Tammy (PI)
  • Make, Barry (PI)
  • Beresford, Thomas (PI)
  • Scherer, Susan (PI)
  • Tyler, Kenneth L. (PI)
  • Bell, Christopher (PI)
  • Wamboldt, Frederick Steven (PI)
  • Hill, James (PI)
  • Kaugars, Astrida (PI)
  • Brandenburg, Suzanne (PI)
  • Liu, Andrew (PI)
  • Kraft, Monica (PI)
  • Schooley, Robert Turner (PI)
  • Rodman, David (PI)
  • Kram, Rodger (PI)
  • Francis, Coni (PI)
  • Crowley, Thomas (PI)
  • Kugelmas, Marcelo (PI)
  • Lowes, Brian (PI)
  • Benson, Constance (PI)
  • Striebich, Christopher (PI)
  • Hoyt, Brian (PI)
  • Wasfi, Yasmine (PI)
  • Sutherland, Julie (PI)
  • Gates, Phillip (PI)
  • Fain, Pamela (PI)
  • Wamboldt, Marianne (PI)
  • O'Reilly, Randall Charles (PI)
  • Seals, Douglas (PI)
  • Kelsay, Kimberly (PI)
  • Gerber, John G. (PI)
  • Newman, Lee (PI)
  • Wenzel, Sally (PI)
  • Farley, Claire (PI)
  • Christou, Demetra (PI)
  • Badesch, David B. (PI)
  • Rewers, Marian J. (PI)
  • Trotter, James F. (PI)
  • Connick, Elizabeth (PI)
  • Eckel, Robert (PI)
  • Bowler, Russell Paul (PI)
  • Barbour, Linda (PI)
  • Hiatt, William Read (PI)
  • Horton, Tracy (PI)
  • Dufour, Darna (PI)
  • Everson, Gregory Thomas (PI)
  • Klinnert, Mary D. (PI)
  • Hutchison, Kent (PI)
  • Schwartz, Robert (PI)
  • Eisenbarth, George (PI)
  • Bergman, Bryan (PI)
  • Wyatt, Holly (PI)
  • Campbell, Thomas (PI)
  • Kohrt, Wendy (PI)
  • Desouza, Christopher (PI)
  • Schenkman, Margaret (PI)
  • Bessesen, Daniel Holland (PI)
  • Bryan, Angela (PI)
  • Krebs, Nancy (PI)
  • Szefler, Stanley James (PI)
  • Voelker, Dennis (PI)
  • van Pelt, Rachael (PI)
  • Fletcher, Courtney V. (PI)
  • Pacheco, Karin (PI)
  • Gottlieb, Peter (PI)
  • Crawford, E. David (PI)
  • Leung, Donald (PI)
  • Regensteiner, Judith (PI)
  • Bender, Bruce G. (PI)
  • Cornier, Marc-Andre (PI)
  • Grigsby, J.I.M. (PI)
  • Wright, Kenneth (PI)
  • Moreau, Kerrie (PI)
  • Bristow, Michael R. (PI)
  • Abraham, Edward (PI)
  • Maier, Lisa (PI)
  • Kiser, Jennifer Justice (PI)
  • Curran, Timothy (PI)
  • Gilden, Donald (PI)
  • Dumont, Larry (PI)
  • Weber, Katherine (PI)
  • Guzelian, Philip (PI)
  • Brooks, Heather (PI)
  • Capell, Warren (PI)
  • Robertson, Michael (PI)
  • Johnson, Daniel (PI)
  • Norwood, Rachel (PI)
  • Manson, Spero (PI)
  • Beske, Stacy (PI)
  • Stob, Nicole (PI)
  • Kosmiski, Lisa (PI)
  • Reusch, Jane (PI)
  • Stodieck, Louis (PI)
  • Wiseman, Alexander (PI)
  • Levi, Marilyn Eckstein (PI)
  • Aquilante, Christina (PI)
  • Melanson, Edward (PI)
  • Zolty, Ronald (PI)
  • Hernandez, Theresa (PI)
  • Perreault, Leigh (PI)
  • Chonchol, Michel Benjamin (PI)
  • Linnebur, Sunny (PI)
  • Craighead, Edward (PI)
  • Christians, U.W.E. (PI)
  • Hoody, Dorie (PI)
  • Quan, Dianna (PI)
  • Albert, Richard (PI)
  • Boackle, Susan A. (PI)
  • Gozansky, Wendolyn (PI)
  • Carten, Monica (PI)
  • Pierce, Gary L. (PI)
  • Barry, D.A.N. (PI)
  • Strom, Laura A. (PI)
  • Rollins, Yvonne (PI)
  • Schrier, Robert (PI)
  • Kozora, Elizabeth (PI)
  • Anderson, Peter (PI)
  • Fontenot, Andrew (PI)
  • Barqawi, A.L. (PI)
  • Higgins, Janine (PI)
  • Haughey, Heather (PI)
  • Donato, Anthony John (PI)
  • Cambier, John C. (PI)
  • Wierman, Margaret (PI)
  • Walders, Natalie (PI)
  • Kirkpatrick, Charles Harvey (PI)
  • Heyn, Patricia (PI)
  • Dreskin, Stephen C. (PI)
  • Hall, Deborah (PI)
  • Draznin, Boris (PI)
  • Corboy, John (PI)
  • Hassell, Kathryn (PI)
  • Liesnewski, Lisa (PI)
  • Lichtenstein, K.E.N. (PI)
  • Echoff, Donald (PI)
  • Stevens, Jennifer (PI)
  • Johnson, Lynn (PI)
  • Kulig, Clark (PI)
  • Haugen, Bryan (PI)
  • Rosen, Hugo Ramon (PI)
  • Striebich, Christopher (PI)
  • Barron, Michelle A. (PI)
  • Bauer, Timothy (PI)
  • Rabinovitch, Nathan (PI)
  • Jankowski, Catherine (PI)
  • Mestroni, Luisa (PI)
  • Milgrom, Henry (PI)
  • Seals, Douglas (PI)
  • Martin, Richard (PI)
  • Aloia, Mark S. (PI)
  • Liu, Andrew (PI)
  • Allen, David (PI)
  • Estacio, Raymond (PI)
  • Bunn, Paul A. (PI)
  • Sussman, Karl (PI)
  • Hayward, Anthony (PI)
  • David, Ikle (PI)
  • Jones, Roy (PI)
  • Robinson, Arthur (PI)
  • McGregor, James (PI)
  • Santhosh-Kumar, C. (PI)
  • Meier, Robert (PI)
  • Pincus, Diane (PI)
  • Belady, Petra (PI)
  • Collier, David (PI)
  • Doherty, Dennis (PI)
  • Neville, Hans (PI)
  • Ringel, Steven (PI)
  • Johnson, Steven (PI)
  • Jones, James (PI)
  • Shrestha, Roshan (PI)
  • Leavey, Patrick (PI)
  • Robinson, William A. (PI)
  • Adler, Lawrence (PI)
  • Wierman, Margaret (PI)
  • Draznin, Boris (PI)
  • Finkel, Terri (PI)
  • Lillehei, Kevin (PI)
  • Krebs, Nancy (PI)
  • Berl, Tomas (PI)
  • Rodman, David (PI)
  • Gabow, Patricia (PI)
  • Donahoo, W. Troy (PI)
  • Kuritzkes, Daniel (PI)
  • Connick, Elizabeth (PI)
  • Eckel, Robert H. (PI)
  • Reusch, Jane (PI)
  • Hiatt, William (PI)
  • Everson, Gregory T. (PI)
  • Klinnert, Mary D. (PI)
  • Lindenfeld, Joann (PI)
  • Ridgway, E. Chester (PI)
  • Haugen, Bryan (PI)
  • Abraham, William (PI)
  • Szefler, Stanley (PI)
  • Wamboldt, Frederick (PI)
  • Hill, James (PI)
  • Gerber, John (PI)
  • Crawford, E. David (PI)
  • Leung, Donald (PI)
  • Regensteiner, Judith (PI)
  • Bristow, Michael (PI)
  • Borish, Larry (PI)
  • Newman, L.E.E. (PI)
  • Schooley, Robert Turner (PI)
  • Nelson, Harold (PI)
  • Hambidge, K. Michael (PI)
  • Krugman, Richard (PI)

Project: Research project

Description

A specific genetic strain of Corriedale sheep is used as an animal model
for the study of liver pathophysiology, specifically, hyperbilirubinemia
(Dubin-Johnson Syndrome). This project is concerned with increasing the
numbers of animals available for research by the controlled breeding of
individuals which genetically transmit this character. This project is
utilizing what is considered to be the only existing Corriedale sheep
homozygotic for this trait. Efforts are being made to obtain both
homozygous and heterozygous offspring from these highly inbred individuals.
Semen collected artificially from the homozygotic rams was diluted in
various cryoprotective extenders and then freeze preserved. This will
ensure the long term availability of male gametes for artificial
insemination. Overall this project allows prepetuation of this specific
gene pool and ensures availability of research animal for future
investigations of Dubin-Johnson Syndrome and related metabolic disorders.
StatusFinished
Effective start/end date12/1/783/31/10

Funding

  • National Institutes of Health

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Corriedale
hyperbilirubinemia
metabolic diseases
pathophysiology
rams
laboratory animals
semen
germ cells
animals
sheep
liver
breeding

ASJC

  • Medicine(all)