REPRODUCTION AND SURVIVAL AFTER CARDIAC DEFECT REPAIR

    Project: Research project

    Project Details

    Description

    In the last 25 years, surgical advances have led to correction of
    congenital heart defects (CHD) in children who otherwise would
    not have lived to adulthood. This study has two major
    objectives: 1) to determine mortality, morbidity (reoperation,
    arrhythmias, endocarditis), and disability after repair of CHD,
    and the major risk factors which predict these events; and 2) to
    assess the safety of pregnancy to women with corrected CHD,
    and the risk of prematurity and recurrence of CHD in offspring. This study would create a registry comprised of all Oregon
    children undergoing surgical repair of CHD and would study the
    eight most prevalent defects: ventricular septal defect (VSD),
    atrial septal defect (ASD), pulmonic stenosis (PS), tetralogy of
    Fallot (TOF), coarctation of the aorta, aortic stenosis (AS),
    transposition of the great arteries (TGA), and patent ductus
    arteriosus (PDA). This proposal is an extension of an identical
    project complied by the investigators for TOF (N=310), VSD
    (N=217), and ASD (N=287). 87% of all subjects were successfully
    followed with a median of 9 years of observation; more than 85
    subjects have been followed for more than 20 years. All cases of surgical correction of PS, AS, TGA, PDA and
    coarctation performed in children age 18 or younger in Oregon
    from 1958 to 1981 will be added to the registry. Preoperative,
    operative and postoperative data for each patient will be entered
    into the data base at chart review. Follow-up for each patient
    will be gathered by mailed questionnaire, telephone survey, and
    the National Death Index. Questionnaires will assess major
    morbidity, functional status and reproduction; pregnancy and
    major events will be confirmed from physician's records.
    Follow-up for TOF, VSD and ASD will be conducted in years 1, 3
    and 5 and for TGA, AS, PS, PDA and coarctation in years 2 and
    4. Chart review will be completed in year 2, and cases will then
    be prospectively identified. Actuarial analysis and the Cox proportional hazards model will
    determine mortality, major morbidity and their risk factors.
    Reproductive data will be analyzed per years of fertility for the
    cohort, and compared to Oregon population statistics. This study will add knowledge of late survival and morbidity of a
    population which is rapidly growing in size, adults with corrected
    CHD. Additionally, we will gather the first prospective
    population data on pregnancy and outcome after repair of CHD;
    this is vital as more adults than ever before with CHD are of
    child-bearing age.
    StatusFinished
    Effective start/end date8/1/8712/31/98

    Funding

    • National Institutes of Health: $89,432.00
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health: $113,925.00
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health: $121,519.00
    • National Institutes of Health
    • National Institutes of Health: $133,234.00

    ASJC

    • Medicine(all)

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