REGULATION OF SYNAPTIC AMINO ACID RECEPTORS

Project: Research project

Description

Glutamate receptors play an essential role in mediating rapid excitatory
synaptic activity in the vertebrate brain. It is possible that some
disorders, such as epilepsy or anoxic damage, are related to changes in
synaptic function, and ultimately, the properties of subsynaptic glutamate
receptors. Thus, effective treatment for such disorders may come from an
understanding of how the receptors are used and regulated. This
information will also be needed to understand the control of signalling by
rapid excitatory synapses. For example, in the auditory system, the
ability to transmit rapid, ongoing, precisely timed signals is critical for
conveying sensory information. Pharmacological experiments have indicated
that antagonists of glutamate receptors block synaptic transmission between
the large calyceal endings of the eighth cranial, or auditory, nerve fibers
and postsynaptic cell bodies in the nucleus magnucellularis (NM) of the
chicken, indicating that glutamate receptors mediate the response. These
glutamate receptors are the focus of the proposed research. As the cells
of the NM have few, if any, dendrites, and the major input for the auditory
nerve is on the cell bodies, glutamate receptors on these cells must be
restricted to the cell bodies. These receptors are therefore ideally
situated for patch clamp studies on NM slices. Experiments are proposed
to identify the subtypes of receptors, their role in the synaptic impulse
and how the synaptic impulse is terminated, as well as the regulation of
receptor distribution, kinetics and conductance by innervation and
denervation. These experiments will be done under visual control at
identified synaptic sites using video imaging techniques.
StatusActive
Effective start/end date5/1/914/30/21

Funding

  • National Institutes of Health
  • National Institutes of Health: $428,816.00
  • National Institutes of Health: $204,952.00
  • National Institutes of Health: $343,527.00
  • National Institutes of Health: $54,500.00
  • National Institutes of Health: $441,449.00
  • National Institutes of Health: $187,560.00
  • National Institutes of Health: $333,507.00
  • National Institutes of Health: $325,085.00
  • National Institutes of Health: $336,875.00
  • National Institutes of Health: $340,982.00
  • National Institutes of Health: $193,188.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $331,093.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $336,875.00
  • National Institutes of Health: $449,919.00
  • National Institutes of Health: $336,875.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $340,460.00
  • National Institutes of Health
  • National Institutes of Health: $432,413.00
  • National Institutes of Health: $198,982.00
  • National Institutes of Health

Fingerprint

Amino Acid Receptors
Synapses
Cochlear Nucleus
Neurons
Dendrites
Glutamate Receptors
Brain
Action Potentials
Interneurons
Axons
Cochlear Nerve
Glutamic Acid
Epilepsy
Synaptic Potentials

ASJC

  • Medicine(all)
  • Neuroscience(all)