REGULATION OF PROLACTIN SYNTHESIS

Project: Research project

Project Details

Description

Studies of monolayer cultures of dispersed pituitary cells have shown that
ergocryptine and other dopaminergic drugs inhibit prolactin synthesis and
decrease prolactin mRNA levels. It was also found that dopaminergic drugs
stimulate the degradation of newly synthesized prolactin. Future work will
investigate whether the dopaminergic regulation of prolactin mRNA levels
involves changes in the transcription of the prolactin gene or in the stability
of prolactin mRNA. These studies will utilize pulse and pulse-chase labeling of
cultured pituitary cells. Studies of prolactin gene transcription will also
utilize isolated pituitary cell nuclei.
StatusFinished
Effective start/end date4/1/788/31/86

Funding

  • National Institutes of Health

ASJC

  • Medicine(all)

Fingerprint Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.