• Leachman, Sancy (PI)
  • Parkin, James (PI)
  • Jarcho, Leonard (PI)
  • Rothstein, Gerald (PI)
  • Galinsky, Raymond (PI)
  • Ellis, Gary (PI)
  • Wender, Paul (PI)
  • Moyer-Mileur, Laurie (PI)
  • Grosser, Bernard (PI)
  • Overall, James (PI)
  • Saffle, Jeffrey (PI)
  • Tyler, Frank (PI)
  • Dukes, George (PI)
  • Fineman, Robert (PI)
  • Stephen, Robert (PI)
  • Moyer, Mileur (PI)
  • Miller, Franklin (PI)
  • Eyre, Harmon (PI)
  • Cashdan, Elizabeth (PI)
  • Wood, David (PI)
  • Molteni, Richard (PI)
  • Turner, Miriam (PI)
  • Nelson, Don (PI)
  • Kochenour, Neil (PI)
  • Bray, Patrick (PI)
  • Meyer, Laurence (PI)
  • Atkin, Curtis (PI)
  • Schipke, Constance (PI)
  • Jung, August Larry (PI)
  • Kolff, Willem (PI)
  • Becker, James (PI)
  • Devries, William (PI)
  • Moody, Frank (PI)
  • Dixon, John (PI)
  • Street, J. (PI)
  • Siegler, Richard (PI)
  • Anderson, Kelley (PI)
  • Trunnell, Eric (PI)
  • Keye, William (PI)
  • Green, Larry (PI)
  • Luetkemeier, Maurie (PI)
  • Carroll, William (PI)
  • Smith, David (PI)
  • Thompson, Marietta (PI)
  • Squire, Susan (PI)
  • Clegg, Daniel (PI)
  • Stanley, T.E.D. (PI)
  • Ziter, Fred (PI)
  • Rikkers, Layton (PI)
  • Edwards, Corwin (PI)
  • Jenkins, Ronald (PI)
  • Taylor, Andrew (PI)
  • Hoidal, John (PI)
  • Jubiz, William (PI)
  • West, Charles (PI)
  • Crandall, Alan (PI)
  • Madsen, Jack (PI)
  • Tolman, Keith (PI)
  • Kelly, Thomas (PI)
  • Cho-Ming, Loi (PI)
  • Reimherr, Frederick (PI)
  • Heusner, James (PI)
  • Ekins, Brent (PI)
  • Ohls, Robin (PI)
  • Zlutnick, Steven (PI)
  • Osborn, Anne (PI)
  • Herbst, John (PI)
  • Buchi, Kenneth (PI)
  • Zone, John (PI)
  • Tyler, Frank H. (PI)
  • Samuelson, Cecil (PI)
  • Call, Gregory (PI)
  • White, Raymond (PI)
  • Hale, Devon (PI)
  • Cannon, Grant (PI)
  • Pavia, Andrew (PI)
  • Prescott, Stephen (PI)
  • Mulroy, John (PI)
  • Stevens, Walter (PI)
  • Heibrun, M. (PI)
  • Heilbrun, M. (PI)
  • Rosato-Santos, Harry (PI)
  • Shigeoka, Ann (PI)
  • Bohnsack, John Francis (PI)
  • Kuwada, Scott (PI)
  • Berenson, Malcolm (PI)
  • Bernstein, Paul Steven (PI)
  • Byington, Carrie (PI)
  • Bamshad, Michael (PI)
  • Gregory, Martin (PI)
  • Kaplan, Jerry (PI)
  • Krueger, Gerald (PI)
  • Renlund, Dale (PI)
  • McMahon, William (PI)
  • Hopkins, Paul (PI)
  • Varner, Michael (PI)
  • Betz, A. Lorris (PI)
  • Hawk, C. Terrance (PI)
  • Bruggers, Carol (PI)
  • Weis, Janis (PI)
  • Kriesel, John (PI)
  • Flejter, Wendy (PI)
  • King, Jerald (PI)
  • Bromberg, Mark (PI)
  • Hibbs, John (PI)
  • Jorde, Lynn (PI)
  • Coon, Hilary (PI)
  • McIntyre, Thomas (PI)
  • Ethridge, Susan (PI)
  • Moody, David (PI)
  • Beatty, Patrick (PI)
  • Krueger, J. (PI)
  • Cawthon, Richard Moore (PI)
  • Rollins, Douglas (PI)
  • McClain, Donald (PI)
  • Caplin, Deidre (PI)
  • Shihab, Fuad (PI)
  • Meikle, A. Wayne (PI)
  • Donaldson, David (PI)
  • Samson-Fang, Lisa (PI)
  • Byington, Carrie (PI)
  • Pershing, Lynn (PI)
  • Krueger, Gerald Gene (PI)
  • Grant, Mary Jo Chellis (PI)
  • MacRitchie, A.M.Y. (PI)
  • Munger, Mark (PI)
  • Wheeler, Richard (PI)
  • Mangrum, Shane (PI)
  • Rollins, Douglas (PI)
  • Bamshad, Michael Joseph (PI)
  • Hunt, Steven C. (PI)
  • Null, Donald (PI)
  • Prescott, Stephen (PI)
  • Gilbert, E. Michael (PI)
  • Hopkins, Paul (PI)
  • Beachy, Joanna Christine (PI)
  • Buys, Saundra (PI)
  • Carey, John (PI)
  • Burt, Randall Walter (PI)
  • Viskochil, David (PI)
  • Norton, Peggy (PI)
  • Liou, Theodore (PI)
  • Gleich, Gerald (PI)
  • Swoboda, Kathryn J. (PI)
  • Ward, John Harris (PI)
  • Kushner, James (PI)
  • Shaddy, Robert (PI)
  • Moyer-Mileur, Laurie J. (PI)
  • Singleton, John Robinson (PI)
  • Shami, Paul (PI)
  • Chatfield, Barbara (PI)
  • Jackson, Christopher G. (PI)
  • Lawson, Victoria (PI)
  • Marcus, Robin (PI)
  • Smith, Gordon Stephen (PI)
  • Bromberg, Mark (PI)
  • Wilkins, Diana (PI)
  • Flanigan, Kevin (PI)
  • Yu, Margaret K.- (PI)
  • Adams, Ted (PI)
  • Prahalad, Sampath (PI)
  • Katz, Bradley (PI)
  • Glenn, Martha (PI)
  • Longo, Nicola (PI)
  • Stevenson, David (PI)
  • Leppert, Mark (PI)
  • Murphy, Patricia (PI)
  • Akerley, Wallace Lovell (PI)
  • Fang, John (PI)
  • Ampofo, Kwabena K. (PI)
  • Yost, Christian (PI)
  • Foster, Carol (PI)
  • Munger, Mark (PI)
  • Guthery, Stephen (PI)
  • Smith, A. Gordon (PI)
  • Srivastava, Rajendu (PI)
  • Peterson, Karen (PI)
  • Lund, Kirk (PI)
  • Marks, Melinda (PI)
  • Petajan, Jack (PI)
  • Wilson, Dana (PI)
  • Bushi, Karen (PI)
  • Lorant, Diane (PI)
  • Rodgers, George (PI)
  • Hill, Harry (PI)
  • Askew, E. (PI)
  • Carey, John (PI)
  • Taylor, David (PI)
  • Heath, Hunter (PI)
  • Jung, August (PI)
  • Kanner, Richard (PI)
  • Iverius, Per-Henrik (PI)
  • Elbein, Steven (PI)
  • McGee, Zell (PI)
  • Spruance, Spotswood (PI)
  • Ateshkadi, Arasb (PI)
  • Milley, Ross (PI)
  • Nielson, Dennis (PI)
  • Odell, William (PI)
  • Skolnick, Mark (PI)
  • Moyer-Mileur, Laurie J. (PI)
  • Rollins, Douglas (PI)
  • Branch, D. Ware (PI)
  • Ward, Kenneth (PI)
  • Slattery, Martha (PI)
  • Byerley, William (PI)
  • Roberts, John (PI)
  • Munger, Mark (PI)
  • Ward, John (PI)
  • Williams, Roger (PI)
  • Chan, Gary (PI)
  • Ptacek, Louis (PI)
  • Burt, Randall (PI)
  • Meikle, A. Wayne (PI)
  • Viskochil, David (PI)
  • Samlowski, Wolfram (PI)
  • Buys, Saundra (PI)
  • Lugo, Ralph (PI)
  • Campbell, Edward (PI)
  • Kushner, James (PI)
  • Marshall, Bruce (PI)
  • Botkin, Jeffrey Robert (PI)
  • Rallison, Marvin (PI)
  • Schibler, Kurt (PI)
  • Brothman, Arthur (PI)
  • Gilbert, Edward (PI)
  • Shaddy, Robert (PI)
  • Keating, Mark (PI)
  • Disario, James (PI)

Project: Research project

Project Details


This research is directed at determining the pattern of hormone response
that governs the Na+ transport properties of the cortical collecting duct
(CCD) from prehypertensive spontaneously hypertensive rats (SHR), and
Wistar Kyoto rats (WKY). Among the hormone effects to be examined will be
the interaction between aldosterone and vasopressin (AVP) in stimulating
Na+ reabsorption and the inhibitory potential of alpha2-adrenergic
agonists, bradykinin, and atrial natriuretic peptide. It has been
demonstrated that the Sprague-Dawley rat CCD responds to AVP with a rapid
and sustained increase in net NaCl absorption due to an enhancement of Na+
entry across the luminal membrane via amiloride inhibitable, conductive
channels. This stimulatory effect of AVP is potentiated by aldosterone.
These results suggest a rationale for the requirement of vasopressin in
some models of hypertension because the two could interact to cause salt
retention. It is presently unknown whether there is any effect of AVP
alone, or if there is an additive effect of AVP with aldosterone on the CCD
of SHR or WKY rats. About 150 male, pathogen-free, SHR rats and 50 male,
pathogen-free, WKY rats per year will be the source of the cortical
collecting ducts. Approximately half of each strain will receive
subcutaneous implants of aldosterone (the other half will be anesthetized
and implanted with pellets collecting tubules. The standard isolated
perfused tubule technique will be used to study the alterations in
unidirectional lumen-to-bath isotopic Na+ flux and changes in
transepithelial voltage when the various hormones and autacoids listed
above are added to the bathing solution. To further characterize the
mechanisms of Na+ transport, amiloride will be added to the perfusate.
This will indicate the fraction of he observed Na+ flux which occurs
through an amiloride-sensitive, electrogenic pathway versus a putative
electroneutral cotransport pathway or by free diffusion through the
paracellular pathway.
Effective start/end date12/1/772/28/11


  • National Institutes of Health


  • Medicine(all)


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