REGULATION OF GLYCOGEN SYNTHASE AND SYNTHASE KINASES

  • Soderling, Thomas, (PI)

    Project: Research project

    Project Details

    Description

    An investigation will be made of the properties and regulation of glycogen
    synthase in rabbit muscle and liver in vitro and in vivo. Synthase kinases
    will be purified and characterized from muscle and liver. Regulation of
    kinases by calcium, calmodulin, and cyclic nucleotides will be examined.
    Relationships between phosphorylation, activity, and structure of synthase
    will be studied. Binding of glucose-6-P and UDP-glucose to muscle synthase
    will be determined. Phosphorylation of synthase in vivo will be studied in
    response to epinephrine, insulin, and diabetes. Effects of somatostatin
    infusion will be examined. The in vivo phosphorylation state of each of
    the sites in muscle synthase will be determined by analysis of tryptic
    peptides separated by high performance liquid chromatography.
    StatusFinished
    Effective start/end date7/1/786/30/88

    Funding

    • National Institutes of Health

    ASJC

    • Medicine(all)

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