PROGRAM PROJECT IN THE PATHOPHYSIOLOGY OF HUMAN GROWTH

  • Rotwein, Peter, (PI)
  • Gavin, James R. (PI)
  • Daughaday, William (PI)
  • Heath-Monnig, Ellen (PI)
  • Bier, Dennis (PI)
  • Fant, Michael E. (PI)
  • Pike, Linda (PI)
  • Tollefsen, Sherida (PI)

    Project: Research project

    Description

    The long-term objective of this program project is to characterize
    mechanisms by which children both grow appropriately and fail to achieve
    normal stature. Following classification by conventional clinical
    characteristics, growth hormone and IGF I secretory criteia: (1) potential
    mutations in hGH and IGF I genes will be sought, polymorphism within and
    around these genes examined, and the regulation of these genes studied.
    (2) Structural abnormalities in circulating hGH and IGF peptides will be
    characterized and their receptor affinities and biologic activities
    quantified. (3) Structural defects of the hGH receptor will be delineated
    and the oligosaccharide unit structure, biosynthesis, and turnover of IGF
    receptors determined. (4) Possible aberrant post-receptor events will be
    defined, and (5) The in vivo significance and clinical consequences of
    these disturbances will be investigated with multi-faceted stable-isotope
    kinetic probes of protein anabolic and catabolic responses to exogenous
    growth hormone administration.
    StatusFinished
    Effective start/end date1/1/866/30/98

    Funding

    • National Institutes of Health: $558,799.00
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health

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    Insulin-Like Growth Factor I
    Genes
    Growth Hormone
    Growth
    Gene Expression
    Intercellular Signaling Peptides and Proteins
    Growth Disorders
    Hormones
    Oligosaccharides
    Nucleic Acid Regulatory Sequences
    Peptides
    Proteins
    Protein Biosynthesis
    Insulin-Like Growth Factor II
    Insulin
    Signal Transduction
    Genetic Promoter Regions
    IGF Type 1 Receptor

    ASJC

    • Medicine(all)