(PQD6) Hypothalamic Inflammation in the Initiation of Cachexia

    Project: Research project

    Description

    DESCRIPTION (provided by applicant): Cachexia, or disease-associated wasting, is a common occurrence in cancer, renal failure, and infectious disease. This devastating state of malnutrition is brought about by a synergistic combination of a decrease in appetite and an increase in metabolism of fat and lean body mass. The severity of cachexia in many illnesses is the primary determining factor in both quality of life, and in eventual mortality. Other illness-induced morbidities including lethargy also compromise the ability of patients to recover from potentially life-saving or extending interventions, and diminish the motivational drive to aggressively battle the condition. Although cachexia in chronic disease was described more than two thousand years ago, the central mechanisms underlying this disorder of energy homeostasis are poorly understood. Furthermore, there is currently no effective pharmaceutical treatment. Our laboratory has dedicated the last decade to unraveling the basic neuroscience of cachexia. In this proposal, we will focus on understanding the scope and mechanism by which peripheral inflammatory insults are received, amplified, and maintained by the hypothalamus. The significance of this proposal resides in its unique combination of our historical focus on neuroendocrinology and behavior, with new collaborations and efforts directed at understanding proximal neuroinflammatory events. The long-term goal of our research is to gain mechanistic understanding of the acute illness response and how it is transitioned into chronic inflammation-associated cachexia in order to develop more effective therapeutic interventions.
    StatusFinished
    Effective start/end date7/1/146/30/18

    Funding

    • National Institutes of Health: $422,399.00
    • National Institutes of Health: $422,399.00
    • National Institutes of Health: $422,399.00
    • National Institutes of Health: $100,000.00

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    Cachexia
    Inflammation
    Neuroendocrinology
    Wasting Syndrome
    Lethargy
    Aptitude
    Appetite
    Neurosciences
    Malnutrition
    Hypothalamus
    Renal Insufficiency
    Communicable Diseases
    Homeostasis
    Chronic Disease
    Fats
    Quality of Life
    Morbidity
    Mortality
    Therapeutics
    Research

    ASJC

    • Medicine(all)