PLACENTAL DEFECTS UNDERLIE FETAL WATER DISEASE

    Project: Research project

    Project Details

    Description

    Fetal water diseases, which include hydrops fetalis and polyhydramnios,
    are an increasingly common cause of infant mortality and morbidity. Nearly
    all fetuses with the non-immune form do not survive. Yet the mechanisms
    that underlie the pathophysiology are unknown. This application is based
    on the umbrella hypothesis that a number of primary fetal abnormalities
    cause fetal water diseases through a common pathway-alterations in the
    physicochemical properties of the placental barrier. The application is
    designed to quantitate missing pieces of data that will allow us to
    estimate the physical forces that regulate the movement of water across
    the placenta in normal and diseased patients. Aim l of the study is to
    measure the diffusion permeability of the tracer substances of different
    molecular weights and charges in normal placentas from pregnancies with
    water disease. Aim 2 is to estimate the hydraulic conductivity and
    reflection coefficients of several important molecular species from the in
    vitro perfused placentas of hydropic and polyhydramniotic patients and
    from normal control patients. The data for these two specific aims will
    provide the basis for predicting the roles of disturbances in the forces
    that drive water across the placenta under normal and pathological
    conditions.
    StatusFinished
    Effective start/end date8/1/947/31/99

    Funding

    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health

    ASJC

    • Medicine(all)

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