PERIPHERAL AND CENTRAL POSTURAL DISORDERS IN THE ELDERLY

Project: Research project

Description

Automatic postural adjustments responsible for human balance will be
studied in young and old normal adults, in patients with disorders of
posture control, and in elderly people with undiagnosed falling problems.
The goal of these studies are 1) to define, quantitatively, the normal
repertoire of postural movement strategies in standing humans for different
speeds and amplitudes, 2) to determine the effects of peripheral sensory
versus central cerebellar disorders on selection and parameterization of
postural strategies and approach, and 3) to determine whether falling in
the elderly can be related to specific peripheral or central nervous system
degeneration. Subjects will stand on a movable platform system. Postural adjustments to
a variety of different movement perturbations will be described by
analyzing the EMG activity of selected leg and lower trunk muscles and by
recording surface forces and motions of the ankle, knee, hip and neck
angles. Experiments are designed to test the hypothesis that the CNS
preprograms a discrete set of automatic postural strategies, each which is
normally triggered within bounded stimulus conditions and that these
boundaries can change with neural pathology causing postural instability in
the elderly. We predict that peripheral sensory system loss will primarily
affect the stimulus boundaries from which intact postural responses are
selected whereas central (cerebellar) damage will affect both the internal
structure of the postural response and the ability to use prior experience
to 'fine tune' the response. Initially, select groups of young and old patients with well-defined
peripheral vestibular deficits, peripheral neuropathy and cerebellar
deficits will be studied. Results will be used to determine if specific
components of postural dyscontrol could be used to identify specific
peripheral and central nervous system degenerations in elderly people with
well-documented stability problems.
StatusFinished
Effective start/end date9/1/863/31/19

Funding

  • National Institutes of Health: $36,000.00
  • National Institutes of Health
  • National Institutes of Health: $450,539.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $475,410.00
  • National Institutes of Health: $482,017.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $631,389.00
  • National Institutes of Health: $5,000.00
  • National Institutes of Health: $488,207.00
  • National Institutes of Health: $208,874.00
  • National Institutes of Health: $424,961.00
  • National Institutes of Health: $5,000.00
  • National Institutes of Health: $463,305.00
  • National Institutes of Health: $612,446.00
  • National Institutes of Health: $423,191.00
  • National Institutes of Health: $631,389.00
  • National Institutes of Health: $95,545.00
  • National Institutes of Health: $424,595.00
  • National Institutes of Health: $5,000.00
  • National Institutes of Health: $390,222.00
  • National Institutes of Health
  • National Institutes of Health: $476,351.00
  • National Institutes of Health
  • National Institutes of Health: $5,000.00
  • National Institutes of Health
  • National Institutes of Health: $460,222.00
  • National Institutes of Health: $427,328.00
  • National Institutes of Health: $421,284.00
  • National Institutes of Health: $5,000.00
  • National Institutes of Health: $5,000.00
  • National Institutes of Health: $510,833.00
  • National Institutes of Health: $431,526.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $5,000.00
  • National Institutes of Health
  • National Institutes of Health: $25,336.00

Fingerprint

Parkinson Disease
Posture
Kinesthesis
Rehabilitation
Basal Ganglia Diseases
Accidental Falls
Leg
Canes
Basal Ganglia
Joints
Levodopa
Healthy Volunteers
Ankle
Cerebellar Diseases
Gait
Biomechanical Phenomena
Proprioception
Foot
Torso
Neurologic Gait Disorders

ASJC

  • Medicine(all)