• Bagby, Grover (PI)

Project: Research project

Project Details


Since its involvement in the Polycythemia Vera Study Group and the
Southwest Oncology group in the 1960s, faculty members at Oregon Health
Sciences University have been vigorous participants in the clinical cancer
research activities of a number of multi-institutional study groups. Only
more recently, however, have steps been taken to systematically strengthen
other components of our cancer research program. In the past 5 years
funded peer-reviewed basic cancer research projects at OHSU have increased
substantially. Kaiser Permanente oncologist and scientists at the Kaiser
Permanente Center for Health Research have not only participated
administratively and clinically, in multi-institutional study groups (NSABP
and SWOG), for over 20 years they have actively and productively focused on
studies of cancer screening, cancer control, and epidemiology. Of most
significant importance to this proposal is the development, last year, of a
comprehensive multi-institutional agreement to collaborate in cancer
research; an agreement that involves OHSU and its institutes, schools and
hospitals, Kaiser-Permanente, the Kaiser Permanente Center for Health
Research, and the Portland Veterans Affairs Medical Center. This
consortium is now beginning to serve as a focus for collaborative clinical
and cancer control research and, because of the size of the populations
served, will permit the development of our own clinical studies. This
consortium serves as the foundation for the Oregon Cancer Center proposed
here. This will be the only comprehensive cancer center in our state. Coordination of these activities and the development of essential new
programs will require comprehensive planning - planning for which we here
seek support - so that our center will serve to optimally encourage new
basic studies in molecular and cellular oncology and provide a springboard
for interdisciplinary programs in cancer research with an emphasis on
bench-to-bedside linkage. There are five organ-site programs upon which we
intend to focus initially; breast, hematologic, neuro-endocrine,
colorectal, and head and neck. We have chosen these programs, in large
part, because strengths already exist in these areas. For the same
reasons, we have chosen to develop four general scientific programs to
interdigitate with these clinical programs. They include: molecular and
cellular oncology, experimental therapeutics, biostatistics, and
epidemiology and public health. Seven shared core facilities will support
these collaborative studies, including laboratories for tumor procurement,
molecular biology (DNA synthesis, peptide synthesis, and protein
microsequencing), biostatistics and data analysis, transgenic animals,
cytogenetics, immunohistochemistry, and flow cytometry. All but the tumor
procurement core are fully equipped and independently functional at this
time. By providing a mechanism by which basic and clinical cancer
scientists will be encouraged to develop collaborative studies, by
utilizing existing institutional commitments and resources in rural health
care targeting medically underserved communities, and by optimizing use of
medical informatics technology, our cancer center, located on the campus of
the only health sciences university in the State of Oregon, will contribute
not only to improved health or Oregonians, but to the development of new
knowledge that may have a considerable impact on human health in general.
Effective start/end date7/6/9212/31/96


  • National Institutes of Health: $113,762.00
  • National Institutes of Health: $261,968.00


  • Medicine(all)


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