• Bagby, Grover (PI)

    Project: Research project

    Project Details


    Since its involvement in the Polycythemia Vera Study Group and the
    Southwest Oncology group in the 1960s, faculty members at Oregon Health
    Sciences University have been vigorous participants in the clinical cancer
    research activities of a number of multi-institutional study groups. Only
    more recently, however, have steps been taken to systematically strengthen
    other components of our cancer research program. In the past 5 years
    funded peer-reviewed basic cancer research projects at OHSU have increased
    substantially. Kaiser Permanente oncologist and scientists at the Kaiser
    Permanente Center for Health Research have not only participated
    administratively and clinically, in multi-institutional study groups (NSABP
    and SWOG), for over 20 years they have actively and productively focused on
    studies of cancer screening, cancer control, and epidemiology. Of most
    significant importance to this proposal is the development, last year, of a
    comprehensive multi-institutional agreement to collaborate in cancer
    research; an agreement that involves OHSU and its institutes, schools and
    hospitals, Kaiser-Permanente, the Kaiser Permanente Center for Health
    Research, and the Portland Veterans Affairs Medical Center. This
    consortium is now beginning to serve as a focus for collaborative clinical
    and cancer control research and, because of the size of the populations
    served, will permit the development of our own clinical studies. This
    consortium serves as the foundation for the Oregon Cancer Center proposed
    here. This will be the only comprehensive cancer center in our state. Coordination of these activities and the development of essential new
    programs will require comprehensive planning - planning for which we here
    seek support - so that our center will serve to optimally encourage new
    basic studies in molecular and cellular oncology and provide a springboard
    for interdisciplinary programs in cancer research with an emphasis on
    bench-to-bedside linkage. There are five organ-site programs upon which we
    intend to focus initially; breast, hematologic, neuro-endocrine,
    colorectal, and head and neck. We have chosen these programs, in large
    part, because strengths already exist in these areas. For the same
    reasons, we have chosen to develop four general scientific programs to
    interdigitate with these clinical programs. They include: molecular and
    cellular oncology, experimental therapeutics, biostatistics, and
    epidemiology and public health. Seven shared core facilities will support
    these collaborative studies, including laboratories for tumor procurement,
    molecular biology (DNA synthesis, peptide synthesis, and protein
    microsequencing), biostatistics and data analysis, transgenic animals,
    cytogenetics, immunohistochemistry, and flow cytometry. All but the tumor
    procurement core are fully equipped and independently functional at this
    time. By providing a mechanism by which basic and clinical cancer
    scientists will be encouraged to develop collaborative studies, by
    utilizing existing institutional commitments and resources in rural health
    care targeting medically underserved communities, and by optimizing use of
    medical informatics technology, our cancer center, located on the campus of
    the only health sciences university in the State of Oregon, will contribute
    not only to improved health or Oregonians, but to the development of new
    knowledge that may have a considerable impact on human health in general.
    Effective start/end date7/6/9212/31/96


    • National Institutes of Health: $113,762.00
    • National Institutes of Health
    • National Institutes of Health: $261,968.00
    • National Institutes of Health


    • Medicine(all)


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