NEUROENDOCRINOLOGY OF PUBERTY AND SEXUAL DEVELOPMENT

    Project: Research project

    Project Details

    Description

    The proposal is aimed at gaining new insight into the developmental
    processes that underlie the maturation of the reproductive hypothalamus
    and, hence, the onset of female puberty. Utilizing the rat as the animal
    model, experiments are proposed to examine the hypothesis that brain
    neuronotrophic factors regulate the development of the hypothalamic LHRH-
    secreting system, which culminates when a discharge of LHRH release
    triggers the first preovulatory surge of gonadotropins. To this end, the
    following specific aims are proposed. 1. To document the hypothesis that nerve growth factor (NGF) and
    transforming growth factor alpha (TGFalpha), as well as their respective
    receptors, are expressed in the hypothalamus, and to examine their
    contribution to the developmental regulation of LHRH secretion. 2. To examine the hypothesis that TGFalpha facilitates the morphological
    and functional differentiation of LHRH neurons and to determine whether NGF
    is trophic for LHRH neurons and/or a neuronal system regulatory to LHRH
    function. 3. To examine the hypothesis that hypothalamic trophic factors, and in
    particular the epidermal growth factor receptor EGFr/TGFalpha ligand system
    can influence LHRH synthesis by directly regulating transcriptional
    activity of the LHRH gene. 4. To examine the hypothesis that TGFalpha is one of the neuronotrophic
    factors that contribute to the peripubertal, gonadal-independent activation
    of LHRH release. The accomplishment of these aims depends on the team participation of one
    neuroendocrinologist, one molecular biologist, and two morphologists, and
    on the integrated use of neuroendocrine, neurobiology and molecular biology
    approaches.
    StatusFinished
    Effective start/end date9/1/906/30/11

    Funding

    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health: $374,207.00
    • National Institutes of Health
    • National Institutes of Health: $369,311.00
    • National Institutes of Health: $371,151.00
    • National Institutes of Health
    • National Institutes of Health: $382,727.00
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health: $366,177.00
    • National Institutes of Health: $356,236.00
    • National Institutes of Health
    • National Institutes of Health: $360,388.00
    • National Institutes of Health: $364,057.00
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health: $197,976.00
    • National Institutes of Health: $377,879.00
    • National Institutes of Health: $362,151.00
    • National Institutes of Health

    ASJC

    • Medicine(all)

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