NEURAL CONTROL OF THE PREPUBERTAL OVARY

    Project: Research project

    Description

    This application, which during the past 2 1/2 years has been
    supported by an NSF grant, proposes to continue a series of studies
    initiated in 1981 to examine the hypothesis that the developing
    ovary, in addition to its hormonal regulation, is controlled by
    direct neural influences. We propose to analyze this issue by
    utilizing a combination of neuroendocrine, cell biology and
    molecular biology approaches, and have selected the following areas
    of inquiry: 1) To define, utilizing an immunological approach, the
    role of extrinsic noradrenergic nerves in the regulation of
    prepubertal ovarian function, 2) To pursue our recent findings that
    the immature ovary expresses the genes encoding nerve growth factor
    (NGF) and tyrosine hydroxylase (TH), the rate limiting enzyme in
    catecholamine biosynthesis, and test the hypothesis that NGF-
    supported cells of neural origin present in the ovary express the
    TH gene and produce norepinephrine (NE) independent of the presence
    of noradrenergic nerves 3) To examine the hypothesis that the
    content of ovarian vasoactive intestinal peptide (VIP) is directly
    controlled by the central nervous system independent of the
    anterior pituitary, and that VIP is an early neurogenic regulatory
    component of ovarian development able to initiate follicular
    formation and activate the gene expression of key steroidogenic
    enzymes before the immature ovary becomes subjected to gonadotropin
    control 4) To define the role of substance P (SP) and neuropeptide
    Y (NPY) as modulators of ovarian blood flow and 5) To examine the
    presence and functions of calcitonin-gene related peptide (CGRP)
    in the ovary.
    StatusFinished
    Effective start/end date2/1/884/30/13

    Funding

    • National Institutes of Health: $341,530.00
    • National Institutes of Health: $348,146.00
    • National Institutes of Health: $74,701.00
    • National Institutes of Health
    • National Institutes of Health: $296,662.00
    • National Institutes of Health
    • National Institutes of Health: $341,530.00
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health: $338,116.00
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health: $339,503.00
    • National Institutes of Health: $383,272.00
    • National Institutes of Health: $391,126.00
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health: $412,365.00
    • National Institutes of Health
    • National Institutes of Health: $324,591.00
    • National Institutes of Health: $78,814.00
    • National Institutes of Health
    • National Institutes of Health: $402,324.00
    • National Institutes of Health

    Fingerprint

    Ovary
    Nerve Growth Factor
    Ovulation
    Nerve Growth Factors
    Nerve Growth Factor Receptors
    Growth
    Genes
    Endocrine Cells
    Nerve Growth Factor Receptor
    Ovarian Diseases
    Primates
    Granulosa Cells
    Nervous System
    Vasoactive Intestinal Peptide
    Oocytes
    Tyrosine 3-Monooxygenase
    Neurotransmitter Agents
    trkA Receptor
    trkB Receptor
    Catecholamines

    ASJC

    • Medicine(all)