NEURAL CELL-SPECIFIC DELETION OF THE LHRH RECEPTOR GENE

    Project: Research project

    Description

    This application proposes the use of a genetic approach to define the potential roles of luteinizing hormone releasing hormone (LHRH) and its receptors in the brain. Specifically, the investigator proposes to employ the bacteriophage P1-derived Cre-loxP recombination system in a gene targeting approach to selectively delete the LHRH receptor gene from brain neurons and/or astrocytes, without affecting expression of the gene in endocrine tissues, such as the pituitary gland and ovaries.
    StatusFinished
    Effective start/end date3/1/98 → 2/28/02

    Funding

    • National Institutes of Health
    • National Institutes of Health
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    LHRH Receptors
    Bacteriophage P1
    Gene Targeting
    Brain
    Pituitary Gland
    Astrocytes
    Genetic Recombination
    Genes
    Ovary
    Research Personnel
    Gene Expression
    Neurons

    ASJC

    • Medicine(all)