MODULATION OF ACAID BY MONOCLONAL ANTIBODIES TO TSF

Project: Research project

Description

The TNP-ACAID model of ocular immune regulation has provided new insights
into immunoregulatory events associated with the eye. An understanding of
these events, on both a cellular and molecular basis, will provide new
insights into the relationship between the eye and the systemic immune
response. The purpose of this proposal is to apply recent advances in the study of
immune regulation to the investigation of TNP-ACAID. This will be done by
using monoclonal antibodies (MAB) developed by the Principle Investigator
which are specific for murine T-suppressor cells (Ts cells) and their
products (1,2). These antibodies have proven invaluable to the study of
immunoregulatory phenomenon in many systems, and have been used to
specifically eliminate Ts cells both in vivo and in vitro, as well as
purify the biologically active products of these cells to virtual
homogeneity. There have been complex regulatory cell interaction described
in ACAID, therefore, the application of these mab's to TNP-ACAID will
permit more precise definition of the regulatory events associated with the
eye, as well as open new avenues of research toward the modification of the
immune response for the treatment of immunologically mediated ocular
disease.
StatusActive
Effective start/end date4/1/87 → …

Funding

  • National Institutes of Health
  • National Institutes of Health: $24,420.00
  • National Institutes of Health

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Transgenic Rats
HLA-B27 Antigen
Uveitis
Cell Communication
Monoclonal Antibodies
Antibodies
Research

Keywords

  • Medicine(all)