MicroRNA regulation of cell survival in angiogenesis and vessel maturation

Project: Research project

Description

DESCRIPTION (provided by applicant): Aberrant growth of blood vessels termed 'angiogenesis' contributes to the pathology of several human diseases ranging from macular degeneration, retinopathy to inflammation and cancer. Recently small RNAs encoded in the genome termed microRNAs have been implicated in the regulation of diverse physiological processes including angiogenesis. We recently profiled microRNAs during activation of endothelial cells and identified microRNA-132 as a critical regulator of p120RasGAP during pathological neovascularization. In this proposal, I will characterize the role of miR-132/p120RasGAP in cell survival during stress responses in the vasculature using in vitro and in vivo angiogenesis models during the mentored phase. Using these models, in the independent phase, I will analyze the contribution of a different microRNA that functions as a negative regulator of cell survival in vascular cells. These studies will elucidate how distinct microRNA programs govern the balance between the pro and anti-angiogenic states in the vasculature during development and disease.
StatusFinished
Effective start/end date6/1/124/30/17

Funding

  • National Institutes of Health: $244,862.00
  • National Institutes of Health: $97,871.00
  • National Institutes of Health: $97,871.00
  • National Institutes of Health: $238,996.00
  • National Institutes of Health: $249,000.00

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MicroRNAs
Cell Survival
p120 GTPase Activating Protein
Blood Vessels
Pathologic Neovascularization
Macular Degeneration
Endothelial Cells
Genome
Pathology
Inflammation
Physiological Phenomena
Growth
Neoplasms
RNA

ASJC

  • Medicine(all)