Melatonin Studies of Totally Blind Children

  • Lewy, Alfred, (PI)

Project: Research project

Description

DESCRIPTION (provided by applicant): In our recently published study, we have shown that nightly oral administration of 10 mg melatonin can entrain (synchronize) free-running circadian rhythms in eight of nine blind adults to the 24.0-hour day, resulting in improved nighttime sleep and daytime alertness. The one person who did not entrain had the longest pre-treatment free-running period (24.9 h). In addition, we have shown that 10 mg of melatomn has a direct soporific action given to blind subjects when their free-running circadian rhythms are inverted. Most recently, he has found that the dose can be "stepped down" to 0.5 mg in three out of three of these people. We have further found that they could also be entrained to a novo 0.5 mg dose (their longest free-running period was 24.4 h). The pre-treatment period appears to predict the likelihood of entrainment to melatonin and the steady-state phase of entrainment, which is consistent with several important principles established in animal studies. Therefore, our projects are of both clinical and scientific importance. There are approximately 200,000 totally blind people in the U.S. About 50 percent have free-running circadian rhythms, and many are children. The goal of this project will be to determine the efficacy of melatonin treatment at three doses (0.5 mg, 10 mg and 20 mg), with the prediction that the 0.5 mg dose will work only in blind children with relatively short periods (
StatusFinished
Effective start/end date9/1/027/31/12

Funding

  • National Institutes of Health: $338,947.00
  • National Institutes of Health: $338,970.00
  • National Institutes of Health: $338,901.00
  • National Institutes of Health: $338,924.00
  • National Institutes of Health: $385,000.00
  • National Institutes of Health: $385,000.00
  • National Institutes of Health: $330,914.00

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Melatonin
Circadian Rhythm
melatonin
Oral Administration
Sleep
circadian rhythm
Therapeutics
puberty
actigraphy
animal experimentation
emotions
sleep

ASJC

  • Medicine(all)