MACROMOLECULAR DIFFRACTION RESOURCE--MACCHESS

  • Chapman, Michael (PI)
  • Chapman, Michael (PI)
  • Harrison, Steve (PI)
  • Moffat, John (PI)
  • Yonath, A.D.A. (PI)
  • Johnson, Jack (PI)
  • Stubbs, Gerald (PI)
  • Wiley, D.O.N. (PI)
  • Batterman, Boris (PI)
  • Moffat, John Keith (PI)
  • Bilderback, Donald (PI)
  • Feigenson, Gerald William (PI)
  • Thiel, Daniel (PI)
  • Hogle, James (PI)
  • Cerione, Richard A. (PI)
  • Zongchoa, Jia (PI)
  • Abad-Zapatero, Cele (PI)
  • Evans, Stephen (PI)
  • Huang, L.A.N. (PI)
  • Joachimiak, Andrzej (PI)
  • Loll, Patrick (PI)
  • Phillips, Margaret A. (PI)
  • Waterman, Michael (PI)
  • Shoham, Menachem (PI)
  • Ober, Christopher Kemper (PI)
  • Hurley, James (PI)
  • Quiocho, Florante (PI)
  • van Roey, Patrick (PI)
  • Ming, Luo (PI)
  • Huxley, Hugh (PI)
  • Sundstrom, Michael (PI)
  • Helliwell, John (PI)
  • Hackert, Marvin (PI)
  • Wang, Jia-Huai (PI)
  • Zlotnick, Adam (PI)
  • Kretsinger, Robert H. (PI)
  • Forest, Katrina (PI)
  • Almo, Steve (PI)
  • [No Value], Wilhelmus G.J. (PI)
  • Borhani, David (PI)
  • Matthews, Brain (PI)
  • Wolczanski, Peter (PI)
  • Lippard, Stephen (PI)
  • Deisenhofer, Johann (PI)
  • Berghuis, Albert (PI)
  • Ciszak, E.W.A. (PI)
  • Jardetzky, Theodore (PI)
  • Fletterick, Robert (PI)
  • Goldstein, Barry (PI)
  • Stroud, Robert (PI)
  • Saper, Mark (PI)
  • Karplus, P. (PI)
  • Pai, Emil (PI)
  • Weber, Patricia Carol (PI)
  • Burley, Stephen (PI)
  • Newcomer, Marcia E. (PI)
  • Tainer, John (PI)
  • Edwards, Aled (PI)
  • Aggarwal, Aneel K. (PI)
  • Ghosh, Debashis (PI)
  • MacKinnon, Roderick (PI)
  • Christianson, David (PI)
  • Cohen, Carolyn (PI)
  • van Duyne, Gregory (PI)
  • Tong, Liang (PI)
  • Eisenberg, David (PI)
  • Weber, Irene (PI)
  • Mariuzza, Roy (PI)
  • Agard, David (PI)
  • Rosenberg, John (PI)
  • Wiener, Michael C. (PI)
  • Murthy, Krishna (PI)
  • Rastinejad, Fraydoon (PI)
  • Doolitle, Russell (PI)
  • Rich, Alexander (PI)
  • Wilson, Chuck (PI)
  • Getzoff, Elizabeth (PI)
  • Magnus, Karen (PI)
  • Hannick, Linda (PI)
  • Ringe, Dagmar (PI)
  • Prive, G.I.L. (PI)
  • Smith, Janet (PI)
  • Gouaux, James Eric (PI)
  • Ladias, John (PI)
  • Poulos, Thomas Lewis (PI)
  • Zhou, Guangwen Wayne (PI)
  • Brenner, Charles (PI)
  • McMillan, Martin (PI)
  • Knox, James (PI)
  • Marmorstein, Ronen (PI)
  • James, Michael (PI)
  • Wlodawer, Alexander (PI)
  • Cody, Vivian (PI)
  • Nassar, Nicolas (PI)
  • Zongchao, Jia (PI)
  • Darst, Seth (PI)
  • Frolow, Felix (PI)
  • Vohra, Yogesh (PI)
  • Pelletier, Huguette (PI)
  • White, Stephen (PI)
  • Jelinski, Lynn (PI)
  • Wolczanki, Peter (PI)
  • Wu, H.A.O. (PI)
  • Yoder, Marilyn (PI)
  • Youngchang, Kim (PI)
  • Jedrzejas, Mark (PI)
  • Weaver, Arthur (PI)
  • Verdine, Gregory (PI)
  • Ellenberger, Tom E. (PI)
  • Sheng-Xiang, Lin (PI)
  • Eck, Michael (PI)
  • Chen, Xiaomin (PI)
  • Shamoo, Adil Yousif (PI)
  • Eigenbrot, Charles (PI)
  • Mariuzza, Roy (PI)
  • Lavie, Arnon (PI)
  • Lattman, Eaton (PI)
  • Noy, N.O.A. (PI)
  • Blobel, Gunter (PI)
  • Tang, Jordan (PI)
  • Sutton, Roger (PI)
  • Yao, N.A.N. (PI)
  • Prive, G.I.L. (PI)
  • Krawczyk, Thomas (PI)
  • Terzyan, Simon (PI)
  • Ferguson, Kathryn (PI)
  • Zhuli, Wan (PI)
  • [No Value], Stephen L. (PI)
  • Lee, Jie- (PI)
  • Prasas, Venkataram (PI)
  • Lanzilotta, William (PI)
  • Nikolov, Dimitar (PI)
  • Bouvier, Marlene (PI)
  • Shilton, Brian (PI)
  • Harrison, Stephen Coplan (PI)
  • Yigong, Shi (PI)
  • Caffrey, Martin D. (PI)
  • Jianhua, Fu (PI)
  • Narayana, Narendra (PI)
  • Cingolani, Gino (PI)
  • Quan, Hao (PI)
  • Rose, David (PI)
  • Agbandje-McKenna, Mavis (PI)
  • Crane, Brian (PI)
  • Birrane, Gabriel (PI)
  • Nicholson, Linda (PI)
  • Wu, H.A.O. (PI)
  • Dashuang, Shi (PI)
  • Basavappa, Ravi (PI)
  • Zhang, Zhong- (PI)
  • Lipscomb, William (PI)
  • Project, Industry (PI)
  • Cabral, Joao (PI)
  • Wedekind, Joseph (PI)
  • Gehring, Kalle (PI)
  • Miller, Christopher (PI)
  • Ferguson-Miller, Shelagh (PI)
  • Schepartz, Alanna (PI)
  • Yizhi Jane, Tao (PI)
  • Verdine, Gregory (PI)
  • Sundberg, Eric (PI)
  • Zhou, Ming (PI)
  • Marmorstein, Ronen (PI)
  • Varma, Ashok (PI)
  • Song, Tan (PI)
  • Gulick, Andrew (PI)
  • Ling, Hong (PI)
  • Lolis, Elias (PI)
  • Gillilan, Richard (PI)
  • Eisenberg, David (PI)
  • Smilgies, Detlef- (PI)
  • Ferguson, Kathryn (PI)
  • Ailong, Ke (PI)
  • Zongchao, Jia (PI)
  • Tsai, Francis T.F. (PI)
  • Cosgrove, Michael S. (PI)
  • Christendat, Dinesh (PI)
  • Botchkarev, Alexei (PI)
  • Mather, Timothy A. (PI)
  • Chen, Xiaomin (PI)
  • Collins, Ruth (PI)
  • Park, Young (PI)
  • Dominguez, Roberto (PI)
  • Yennawar, Neela H. (PI)
  • Thorne, Robert (PI)
  • Sondermann, Holger (PI)
  • Ghosh, Debashis (PI)
  • Malkowski, Michael (PI)
  • Moonsoo, Jin (PI)
  • Shamoo, Adil Yousif (PI)
  • Ruhlandt-Senge, Karin (PI)
  • Yizhi Jane, Tao (PI)
  • Tsodikov, Oleg (PI)
  • Krasnoff, Stuart (PI)
  • Ramasubbu, Narayanan (PI)
  • Braddock, Demetrios (PI)
  • Nikolov, Dimitar (PI)
  • Boudker, Olga (PI)
  • Boggon, Titus Jonathon (PI)
  • Diesenhofer, Johann (PI)
  • Bochkarev, Alexei (PI)
  • Grahame, David (PI)
  • Iverson, T. (PI)
  • Emil, Pai (PI)
  • Zhou, Ming (PI)
  • Rowlett, Roger (PI)
  • Gulick, Andrew (PI)
  • Kielkopf, Clara (PI)
  • Oswald, Robert (PI)
  • McKenna, Robert (PI)
  • Lobkovsky, Emil (PI)
  • Mariuzza, Roy (PI)
  • Eck, Michael (PI)
  • Aaron, Julie (PI)
  • Aggarwal, Aneel K. (PI)
  • Yoshikawa, Shinya (PI)
  • Melton, Jack (PI)
  • Rose, Robert (PI)
  • Song, Tan (PI)
  • Smilgies, Detlef- (PI)
  • Bingdong, Sha (PI)
  • Berry, Edward (PI)
  • Cosgrove, Michael S. (PI)
  • Ealick, Steven (PI)
  • Houdusse, Anne (PI)
  • Yizhi Jane, Tao (PI)
  • Yan-Yeung, Luk (PI)
  • Chaudhuri, Barnali (PI)
  • Ramasubbu, Narayanan (PI)
  • Noller, Harry (PI)
  • Horne, William Alan (PI)
  • Baker, Edward (PI)
  • Yuxin, Mao (PI)
  • Schlessinger, Joseph (PI)
  • van Duyne, Gregory (PI)
  • Wilkens, Stephan (PI)
  • Collins, Ruth (PI)
  • Drennan, Catherine (PI)
  • Szebenyi, Doletha (PI)
  • Roberts, Jeffrey (PI)
  • Braddock, Demetrios (PI)
  • Gewirth, Daniel (PI)
  • Stuart, Loh (PI)
  • Fromme, J. Christopher (PI)
  • Cingolani, Gino (PI)
  • Steitz, Thomas Arthur (PI)
  • Birrane, Gabriel (PI)
  • Dumont, Mark E. (PI)
  • Schultz, Wayne (PI)
  • Kong, Xiangpeng (PI)
  • Bowman, Gregory Dean (PI)
  • Everse, Stephen (PI)
  • Cody, Vivian (PI)
  • Krasnoff, Stuart (PI)
  • Christendat, Dinesh (PI)
  • Schildbach, Joel (PI)
  • Nikolov, Dimitar (PI)
  • Gruner, Sol (PI)
  • Rose, Robert (PI)
  • Maquat, Lynne (PI)
  • Song, Tan (PI)
  • Murakami, Katsuhiko (PI)
  • Hafenstein, Susan (PI)
  • Dominguez, Roberto (PI)
  • Rose, Joan Bray (PI)
  • Yennawar, Neela H. (PI)
  • Pyle, Anna Marie (PI)
  • Lemmon, Mark A. (PI)
  • Project, Industry (PI)
  • Lima, Enju (PI)
  • Modis, Yorgo (PI)
  • Gillilan, Richard (PI)
  • Englich, Ulrich (PI)
  • Tulinsky, Alexander (PI)
  • Zhao, Baoguang (PI)
  • Karplus, Andrew (PI)
  • Jarketzky, T.E.D. (PI)
  • Howell, P. (PI)
  • Kossiakoff, A.A. (PI)
  • Bjorkman, Pamela (PI)
  • De Vos, Abraham (PI)
  • Cygler, Mirek (PI)
  • Rayment, Ivan (PI)
  • Kornberg, Roger (PI)
  • Smith, Thomas (PI)
  • Johnson, John (PI)
  • Ludwig, Martha (PI)
  • Sheriff, Steven (PI)
  • Rose, David (PI)
  • Mondragon, Alfonso (PI)
  • Doudna, Jennifer (PI)
  • Harrison, Stephen (PI)
  • Pavletich, Nikola (PI)
  • Frederick, Christin (PI)
  • Wiley, Don (PI)
  • Brunger, Axel T. (PI)
  • Yonath, Ada (PI)
  • Sigler, Paul (PI)
  • Sprang, Stephen R. (PI)
  • Kuriyan, John (PI)
  • Clardy, J.O.N. (PI)
  • Rini, James (PI)
  • Steitz, Thomas Arthur (PI)
  • Rossmann, Michael (PI)
  • Ealick, Steven (PI)
  • Gruner, Sol (PI)
  • Arnold, Edward (PI)

Project: Research project

Description

The goal of the MacCHESS Research Resource is to support macromolecular
crystallography at the Cornell High Energy Synchrotron Source (CHESS).
This will be accomplished by developing and providing specialized
instrumentation for crystallographic studies by our national user
community and by performing core research that advances the frontiers of
synchrotron radiation research. We will continue to provide service to
the macromolecular crystallography community with special emphasis on
monochromatic oscillation data collection and MAD phasing techniques.
The facilities at CHESS should be particularly useful for small crystals,
crystals with large unit cells, weakly diffracting crystals and crystals
susceptible to radiation damage. Central to our goal is the development
of more user friendly hardware, software and operational procedures that
will make trips to CHESS more productive. MacCHESS will support
macromolecular crystallography on beamlines A-1 (monochromatic
oscillation data), B-2 (Laue diffraction), F-1 (monochromatic oscillation
data with biohazard containment facilities) and F-2 (MAD phasing).
Access to these experimental stations will be based on the CHESS peer-
reviewed proposal system. Future core research will include
establishment of a centralized data reduction facility, implementation
of CCD-based X-ray detectors, construction of apparatus for MAD phasing
on station F-2, development of microfocusing optics for X-ray diffraction
studies of microcrystals, upgrade of station A-1 to take advantage of the
new A line wiggler, implementation of low-temperature techniques,
investigation of high energy X-ray diffraction, general optics
development and undulator experimentation. In addition, we will continue
to develop software for data collection and analysis and to make the
software more user friendly. MacCHESS will provide trained staff to
assist users in setting up beamlines, designing experiments and
processing X-ray diffraction data. CCD-detector development will be
supplemented by acquisition of additional image plate scanners and
additional electronic and computing equipment will be purchased to
refurbish a synchrotron radiation laboratory that has been productive for
more than ten years. All of these developments will bring nearer the
goal of rapid visualization of macromolecular structure. Finally we will
continue to provide training and dissemination through maintenance of
operation manuals, preparation of a MacChess brochure, on-site
instruction, organization of workshops, presentations at meetings,
presentation of invited seminars and production of training videos for
CHESS facilities and low temperature techniques.
StatusFinished
Effective start/end date9/1/836/30/13

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Dependovirus
Synchrotrons
Radiation
Viruses
Crystallography
crystals
viruses
Technical presentations
Charge coupled devices
Crystals
Genes
Biohazards
Detectors
synchrotrons
X ray diffraction
X rays
Microcrystals
Wigglers
catalysis
Radiation damage

ASJC

  • Medicine(all)