• Belknap, John (PI)
  • Phillips, Tamara (PI)
  • Cunningham, Christopher (PI)
  • Crabbe, John Jr (PI)
  • Keith, L. Donald (PI)
  • Gallaher, Edward (PI)

Project: Research project

Project Details


The central research goal of this new program project application is to
determine the extent of genetic correlation of sensitivity, tolerance, and
withdrawal for several effects of ethanol (EtOH) in mice. Several
responses reflecting EtOH's hedonic, sedative, endocrine, and withdrawal
effects will be analyzed using behavioral, neuropharmacologically specified
mice after acute EtOH to determine the genetic bases for initial
sensitivity to EtOH. They will also be studied after repeated
administrations of EtOH using different responses and patterns of exposure.
The rates of onset and maximal degree of tolerance or sensitization
achieved will be estimated. Two methods will be employed to estimate the
presence of genetic correlations. First, all component projects will study
acute and/or chronic EtOH effects in a battery of 20 Recombinant Inbred
(RI) strains, derived from the parental inbred strains C57BL/6J (C57) and
DBA/2J (DBA). Common use of this panel of RI strains by all projects will
offer several advantages. All projects will be contributing to a central
data base which will offer much more information than if similar studies
were carried out independently. It will also be possible to detect any
potential single gene difference in this data set, and existing indications
of single gene differences in the BXD RI panel described above may be
followed up in the proposed research. The second method to be employed to
estimate genetic correlations will be to study the divergence of
selectively bred mouse lines for the presence of correlated responses.
Lines selected for three different responses to EtOH (WSP/WSR, HOT/COLD,
FAST/SLOW) will be studied. Individual projects will assess one or more of
these selected lines to provide convergent validity of any genetic
correlations assessed in the BXD RI panel.
Effective start/end date8/1/907/31/96


  • National Institutes of Health: $99,500.00
  • National Institutes of Health: $12,091.00
  • National Institutes of Health: $12,499.00


  • Medicine(all)


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