FASEB CONFERENCE/RECOMBINATION AND GENOME REARRANGEMENTS

We request partial funding for an FASEB Summer Research Conference on
Recombination and Genome Rearrangements, to be held July 20-25, 1986 at the
Vermont Academy, Saxton's River, Vermont. The conference is under the
auspices of the Federation of the American Societies of Experimental
Biology (FASEB). The format will be the same as that used by the Gordon
Research Conferences. There will be 9 major sessions with 36 invited
speakers, plus one workshop, as well as poster sessions. The topics to be
covered will be site-specific recombination, biochemistry of recombination
initiation, processing of recombination intermediates, mammalian
recombination systems, transposable sequences, genetic control of
homologous recombination, genome rearrangements and gene expression,
interactions between repeated sequences and molecular models of
recombination. The systems to be focused upon involve bacteria, fungi,
Drosophila and mammalian cells. Both in vitro and in vivo approaches will
be covered. Considerable emphasis will be placed on mammalian cell
systems, especially those dealing with "gene targeting" and integration
into the genome. A better understanding of these latter points is crucial
for the development of gene therapy strategies which are currently being
explored in a number of laboratories for use on a variety of human inborn
errors of metabolism. To the best of our knowledge, this conference will
be the only regularly scheduled meeting that will deal specifically with
genetic recombination and genome rearrangements.