ETHANOL WITHDRAWAL QTLS AND CANDIDATE GENES

Project: Research project

Description

DESCRIPTION: Decreased GABAergic transmission is thought to play an important role in the development of alcohol dependence/withdrawal, but the specific genes responsible for adaptive changes in GABAergic transmission remain to be elucidated. In our studies to date, QTL analysis using three populations derived from the C57BL/6J and DBA/2J inbred mouse strains have identified several loci that contribute to genetic differences in acute alcohol withdrawal severity. One alcohol withdrawal locus (Alcw1) has been localized at a high level of significance (p
StatusActive
Effective start/end date8/1/971/31/21

Funding

  • National Institutes of Health: $343,035.00
  • National Institutes of Health: $346,500.00
  • National Institutes of Health: $260,252.00
  • National Institutes of Health: $50,961.00
  • National Institutes of Health: $107,279.00
  • National Institutes of Health: $329,725.00
  • National Institutes of Health: $76,218.00
  • National Institutes of Health
  • National Institutes of Health: $346,500.00
  • National Institutes of Health: $100,836.00
  • National Institutes of Health: $283,500.00
  • National Institutes of Health: $329,725.00
  • National Institutes of Health: $125,477.00
  • National Institutes of Health: $264,250.00
  • National Institutes of Health: $264,250.00

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Ethanol
Alcoholism
Alcohols
Quantitative Trait Loci
Genes
Inbred Strains Mice
Chromosomes, Human, Pair 4
National Institute on Alcohol Abuse and Alcoholism (U.S.)
Population
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 1
Forensic Anthropology
Gene Regulatory Networks
Alcoholics
Animal Models
Psychiatry
Chromosomes
Alleles
Recurrence

ASJC

  • Medicine(all)