ELECTRIC STUDIES OF EXCITATION AND CONTRACTION

  • Almers, Wolfhard, (PI)

Project: Research project

Description

The aim is to determine how action potentials cause contraction in amphibian
skeletal muscle. Various voltage-clamp techniques will be used to study: 1)
ionic channels contributing to electrical excitability; 2) the potential
dependence and kinetics of contractile activation, and 3) the role of
dielectric displacement currents in the regulation of contraction.
Pharmacological modifications of the excitation-contraction coupling mechanism
and of calcium channels will be compared, combining electrical recording and
fluoresence microscopy.
StatusFinished
Effective start/end date9/1/778/31/86

Funding

  • National Institutes of Health

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Excitation Contraction Coupling
Patch-Clamp Techniques
Calcium Channels
Ion Channels
Action Potentials
Microscopy
Pharmacology
Muscles

ASJC

  • Medicine(all)