Project Details
Description
The aim is to determine how action potentials cause contraction in amphibian
skeletal muscle. Various voltage-clamp techniques will be used to study: 1)
ionic channels contributing to electrical excitability; 2) the potential
dependence and kinetics of contractile activation, and 3) the role of
dielectric displacement currents in the regulation of contraction.
Pharmacological modifications of the excitation-contraction coupling mechanism
and of calcium channels will be compared, combining electrical recording and
fluoresence microscopy.
skeletal muscle. Various voltage-clamp techniques will be used to study: 1)
ionic channels contributing to electrical excitability; 2) the potential
dependence and kinetics of contractile activation, and 3) the role of
dielectric displacement currents in the regulation of contraction.
Pharmacological modifications of the excitation-contraction coupling mechanism
and of calcium channels will be compared, combining electrical recording and
fluoresence microscopy.
| Status | Finished |
|---|---|
| Effective start/end date | 9/1/77 → 8/31/86 |
Funding
- National Institutes of Health
ASJC
- Medicine(all)
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