Project: Research project

    Project Details


    There is no readily available method that can be used to precisely
    assess both regional myocardial perfusion and function in humans.
    It has been recently demonstrated by the principal investigator
    and others that myocardial contrast echocardiography can be
    utilized to define zones of decreased perfusion. Further, two-
    dimensional echocardiography has also been used by the principal
    investigator and others for quantitating regional myocardial
    function. This proposal aims at developing these techniques using
    computer analysis for simultaneous assessment of regional
    perfusion and function, first in the animal model, and later in
    humans. An attempt will be made to understand the relationship
    between myocardial contrast parameters and regional myocardial
    blood flow as measured by radiolabeled microspheres and mean
    coronary transit times using technetium labeled red cells.
    Algorithms will be developed to measure absolute regional
    myocardial blood flow derived from parameters obtained from the
    washout of contrast from the myocardium. It is hoped that this
    research will provide an in-depth understanding of the kinetics of
    microbubbles through the myocardium at different coronary flow
    rates and the effect of flow on the microbubbles. The optimal
    contrast agent and the optimal method for injection of the agent
    without causing a hyperemic response will be developed. The
    effect of this agent on normal and ischemic human myocardium
    will be studied. Although methods for measuring regional
    myocardial function have been previously described, there are
    limitations in these methods which mostly relate to defining the
    center of mass in an ischemic ventricle and overall translation of
    the heart. This proposal defines a new approach for quantifying
    regional myocardial function using a sophisticated computer
    algorithm which is independent of the center of mass and is not
    affected by cardiac translation. Using these techniques, we aim
    to study the relationship between transmural and endocardial
    blood flow and regional myocardial function over varying degrees
    of coronary blood flow. It is also proposed to estimate coronary
    flow reserve in humans prior to and following coronary
    angioplasty to determine if changes in coronary flow reserve
    correlate with the success of coronary angioplasty and the
    restenosis rate following the procedure. It is hoped that these
    methods can be used to assess regional myocardial perfusion and
    function simultaneously in humans using tow-dimensional
    Effective start/end date7/1/876/30/92


    • National Institutes of Health: $103,180.00


    • Medicine(all)


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